BPTF
Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
bromodomain PHD finger transcription factor | MIM:601819 | Ensembl:ENSG00000171634 | HGNC:HGNC:3581 | PA162377557 | 17q24.2 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in BPTF
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0000790 | nuclear chromatin |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005737 | cytoplasm |
CC | IDA | GO:0016589 | NURF complex |
CC | IEA | GO:0030425 | dendrite |
CC | IEA | GO:0044297 | cell body |
CC | IDA | GO:0048188 | Set1C/COMPASS complex |
CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
CC | HDA | GO:0070062 | extracellular exosome |
BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0001892 | embryonic placenta development |
BP | IDA | GO:0006338 | chromatin remodeling |
BP | IMP | GO:0006351 | transcription, DNA-templated |
BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
BP | IMP | GO:0007420 | brain development |
BP | IEA | GO:0007492 | endoderm development |
BP | IEA | GO:0009611 | response to wounding |
BP | IEA | GO:0009952 | anterior/posterior pattern specification |
BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
MF | IDA | GO:0008134 | transcription factor binding |
MF | IEA | GO:0035064 | methylated histone binding |
MF | IDA | GO:0043565 | sequence-specific DNA binding |
MF | IMP | GO:0043565 | sequence-specific DNA binding |
MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: BPTF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD125 | BIRB-796 | 1 |
iGMDRD504 | Obatoclax | 1 |
iGMDRD292 | NSC87877 | 1 |
iGMDRD700 | AUY922 | 1 |
iGMDRD3 | PD-173074 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BPTF