CASP9


Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602234
PHARMGKB IDPA26094
Map Location1p36.21

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in CASP9


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0005634 nucleus
CC IBA GO:0005737 cytoplasm
CC IEA GO:0005739 mitochondrion
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0032991 protein-containing complex
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Gene expression in normal tissue: CASP9

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6

Gene-drug pathway distribution

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Pathways in CASP9


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Database
Pathway ID
Pathway Des.
wikipathways WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathways WP1530 miRNA Regulation of DNA Damage Response
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP1984 Integrated Breast Cancer Pathway
wikipathways WP2059 Alzheimers Disease
wikipathways WP231 TNF alpha Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 3
iGMDRD280 CYTOCHALASIN B 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP9

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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