Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].

caspase 9MIM:602234Ensembl:ENSG00000132906HGNC:HGNC:1511PA260941p36.21

Gene Categories:


GO terms in CASP9

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0032991protein-containing complex
BPIBAGO:0006915apoptotic process
BPIMPGO:0006915apoptotic process
BPTASGO:0006915apoptotic process
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIMPGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPTASGO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
BPTASGO:0030220platelet formation
BPIEAGO:0032025response to cobalt ion
BPIEAGO:0032355response to estradiol
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0034349glial cell apoptotic process
BPIDAGO:0034644cellular response to UV
BPIDAGO:0042770signal transduction in response to DNA damage
BPIMPGO:0043065positive regulation of apoptotic process
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIEAGO:0046677response to antibiotic
BPIEAGO:0071549cellular response to dexamethasone stimulus
BPTASGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIMPGO:2001020regulation of response to DNA damage stimulus
MFIDAGO:0004197cysteine-type endopeptidase activity
MFIPIGO:0005515protein binding
MFTASGO:0008047enzyme activator activity
MFIDAGO:0008233peptidase activity
MFIDAGO:0017124SH3 domain binding
MFIDAGO:0019901protein kinase binding
MFIBAGO:0097153cysteine-type endopeptidase activity involved in apoptotic process

Gene expression in normal tissue: CASP9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASP9

DatabasePathway IDPathway Des.
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP707DNA Damage Response
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05012Parkinson,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
biocartaaktpathwayakt signaling pathway
biocartacaspasepathwaycaspase cascade in apoptosis
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartahsp27pathwaystress induction of hsp regulation
biocartairespathwayinternal ribosome entry pathway
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
biocartaplk3pathwayregulation of cell cycle progression by plk3
biocartaraspathwayras signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartawnvpathwaywest nile virus
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111458Formation of apoptosome
reactomeR-HSA-111459Activation of caspases through apoptosome-mediated cleavage
reactomeR-HSA-111461Cytochrome c-mediated apoptotic response
reactomeR-HSA-111463SMAC binds to IAPs
reactomeR-HSA-111464SMAC-mediated dissociation of IAP:caspase complexes
reactomeR-HSA-111469SMAC-mediated apoptotic response
reactomeR-HSA-111471Apoptotic factor-mediated response
reactomeR-HSA-111471Apoptotic factor-mediated response
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-418889via Dependence Receptors in the absence of ligand
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP9