CLDN1


Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
claudin 1MIM:603718Ensembl:ENSG00000163347HGNC:HGNC:2032PA265573q28

Gene Categories:

DRUG RESISTANCE

GO terms in CLDN1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007568aging
BPIEAGO:0008065establishment of blood-nerve barrier
BPISSGO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0042538hyperosmotic salinity response
BPIMPGO:0045216cell-cell junction organization
BPIEAGO:0045471response to ethanol
BPIEAGO:0046718viral entry into host cell
BPIMPGO:0051260protein homooligomerization
BPIGIGO:0051291protein heterooligomerization
BPIMPGO:0061436establishment of skin barrier
BPIEAGO:0061772drug transport across blood-nerve barrier
BPIEAGO:0070673response to interleukin-18
BPIMPGO:0070830bicellular tight junction assembly
BPIEAGO:0071284cellular response to lead ion
BPIEAGO:0071346cellular response to interferon-gamma
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071548response to dexamethasone
BPIEAGO:0071560cellular response to transforming growth factor beta stimulus
BPIEAGO:0090557establishment of endothelial intestinal barrier
BPIEAGO:0097421liver regeneration
BPIEAGO:1903348positive regulation of bicellular tight junction assembly
BPIEAGO:1903545cellular response to butyrate
CCIEAGO:0005737cytoplasm
CCIMPGO:0005887integral component of plasma membrane
CCIDAGO:0005923bicellular tight junction
CCISSGO:0005923bicellular tight junction
CCTASGO:0016021integral component of membrane
CCIDAGO:0016323basolateral plasma membrane
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0016328lateral plasma membrane
MFIMPGO:0001618virus receptor activity
MFIEAGO:0005198structural molecule activity
MFIPIGO:0005515protein binding
MFISSGO:0042802identical protein binding

Gene expression in normal tissue: CLDN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLDN1


DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-420029Tight junction interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP4239EMT transition in Colorectal Cancer
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
pidnectin_pathwayNectin adhesion pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib2
iGMDRD353PD03259012
iGMDRD131Erlotinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLDN1

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