CLDN1
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| claudin 1 | MIM:603718 | Ensembl:ENSG00000163347 | HGNC:HGNC:2032 | PA26557 | 3q28 |
Gene Categories:
DRUG RESISTANCEGO terms in CLDN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008065 | establishment of blood-nerve barrier |
| BP | ISS | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0042538 | hyperosmotic salinity response |
| BP | IMP | GO:0045216 | cell-cell junction organization |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IMP | GO:0051260 | protein homooligomerization |
| BP | IGI | GO:0051291 | protein heterooligomerization |
| BP | IMP | GO:0061436 | establishment of skin barrier |
| BP | IEA | GO:0061772 | drug transport across blood-nerve barrier |
| BP | IEA | GO:0070673 | response to interleukin-18 |
| BP | IMP | GO:0070830 | bicellular tight junction assembly |
| BP | IEA | GO:0071284 | cellular response to lead ion |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071548 | response to dexamethasone |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:0090557 | establishment of endothelial intestinal barrier |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IEA | GO:1903348 | positive regulation of bicellular tight junction assembly |
| BP | IEA | GO:1903545 | cellular response to butyrate |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | ISS | GO:0005923 | bicellular tight junction |
| CC | TAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| MF | IMP | GO:0001618 | virus receptor activity |
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042802 | identical protein binding |
Gene expression in normal tissue: CLDN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLDN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-420029 | Tight junction interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| pid | nectin_pathway | Nectin adhesion pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD131 | Erlotinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLDN1
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