CRBN


Summary: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cereblonMIM:609262Ensembl:ENSG00000113851HGNC:HGNC:30185PA1349268513p26.2

GO terms in CRBN


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0016567protein ubiquitination
BPIMPGO:0016567protein ubiquitination
BPIEAGO:0032463negative regulation of protein homooligomerization
BPIEAGO:0034766negative regulation of ion transmembrane transport
BPIMPGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIEAGO:0090073positive regulation of protein homodimerization activity
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIEAGO:0016020membrane
CCIDAGO:0031464Cul4A-RING E3 ubiquitin ligase complex
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: CRBN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CRBN


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD115Pomalidomide4
iGMDRD135Lenalidomide4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CRBN

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