CRBN
Summary: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cereblon | MIM:609262 | Ensembl:ENSG00000113851 | HGNC:HGNC:30185 | PA134926851 | 3p26.2 |
GO terms in CRBN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IMP | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0032463 | negative regulation of protein homooligomerization |
| BP | IEA | GO:0034766 | negative regulation of ion transmembrane transport |
| BP | IMP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0090073 | positive regulation of protein homodimerization activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CRBN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CRBN
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CRBN
CLASSFICATION
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