CUL2


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cullin 2MIM:603135Ensembl:ENSG00000108094HGNC:HGNC:2552PA2704810p11.21

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CUL2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0006511ubiquitin-dependent protein catabolic process
BPTASGO:0007050cell cycle arrest
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0016032viral process
BPIEAGO:0016567protein ubiquitination
BPTASGO:0043687post-translational protein modification
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPTASGO:0097193intrinsic apoptotic signaling pathway
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus
CCTASGO:0005829cytosol
CCIEAGO:0030891VCB complex
CCIBAGO:0031461cullin-RING ubiquitin ligase complex
CCIBAGO:0031462Cul2-RING ubiquitin ligase complex
CCIDAGO:0031462Cul2-RING ubiquitin ligase complex
MFIPIGO:0005515protein binding
MFIBAGO:0031625ubiquitin protein ligase binding
MFIDAGO:0031625ubiquitin protein ligase binding
MFIEAGO:0044877protein-containing complex binding
MFIBAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: CUL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CUL2


DatabasePathway IDPathway Des.
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
pidhif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha
wikipathwaysWP4241Type 2 papillary renal cell carcinoma

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD262KU-559331
iGMDRD399Selumetinib1
iGMDRD347Y-399831
iGMDRD507GSK6906931

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CUL2

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