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CUL2

Summary:

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cullin 2	MIM:603135	Ensembl:ENSG00000108094	HGNC:HGNC:2552	PA27048	10p11.21

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CUL2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000082	G1/S transition of mitotic cell cycle
BP	IEA	GO:0006511	ubiquitin-dependent protein catabolic process
BP	TAS	GO:0007050	cell cycle arrest
BP	TAS	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0016032	viral process
BP	IEA	GO:0016567	protein ubiquitination
BP	TAS	GO:0043687	post-translational protein modification
BP	TAS	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
BP	TAS	GO:0097193	intrinsic apoptotic signaling pathway
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005730	nucleolus
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0030891	VCB complex
CC	IBA	GO:0031461	cullin-RING ubiquitin ligase complex
CC	IBA	GO:0031462	Cul2-RING ubiquitin ligase complex
CC	IDA	GO:0031462	Cul2-RING ubiquitin ligase complex
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0031625	ubiquitin protein ligase binding
MF	IDA	GO:0031625	ubiquitin protein ligase binding
MF	IEA	GO:0044877	protein-containing complex binding
MF	IBA	GO:0061630	ubiquitin protein ligase activity

Gene expression in normal tissue: CUL2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CUL2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactome	R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactome	R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactome	R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-2262749	Cellular response to hypoxia
reactome	R-HSA-2262749	Cellular response to hypoxia
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8951664	Neddylation
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9010553	Regulation of expression of SLITs and ROBOs
reactome	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
reactome	R-HSA-983169	Class I MHC mediated antigen processing & presentation
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04120	Ubiquitin mediated proteolysis - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
pid	hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
wikipathways	WP4241	Type 2 papillary renal cell carcinoma

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	1
iGMDRD262	KU-55933	1
iGMDRD399	Selumetinib	1
iGMDRD347	Y-39983	1
iGMDRD507	GSK690693	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CUL2

SITE

DATATYPES

CLASSFICATION

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