ENO2
Summary: This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| enolase 2 | MIM:131360 | Ensembl:ENSG00000111674 | HGNC:HGNC:3353 | PA27788 | 12p13.31 |
GO terms in ENO2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0004634 | phosphopyruvate hydratase activity |
| MF | TAS | GO:0004634 | phosphopyruvate hydratase activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0000015 | phosphopyruvate hydratase complex |
| CC | IEA | GO:0001917 | photoreceptor inner segment |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006094 | gluconeogenesis |
| BP | ISS | GO:0006096 | glycolytic process |
| BP | TAS | GO:0061621 | canonical glycolysis |
Gene expression in normal tissue: ENO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ENO2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TCR | TCR |
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| humancyc | PWY66-399 | gluconeogenesis |
| humancyc | PWY66-400 | glycolysis |
| humancyc | PWY66-407 | superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP534 | Glycolysis and Gluconeogenesis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70263 | Gluconeogenesis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ENO2
CLASSFICATION
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