FAT1
Summary: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
FAT atypical cadherin 1 | MIM:600976 | Ensembl:ENSG00000083857 | HGNC:HGNC:3595 | PA164719952 | 4q35.2 |
GO terms in FAT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0007015 | actin filament organization |
BP | TAS | GO:0007155 | cell adhesion |
BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
BP | ISS | GO:0007163 | establishment or maintenance of cell polarity |
BP | TAS | GO:0007267 | cell-cell signaling |
BP | TAS | GO:0009653 | anatomical structure morphogenesis |
BP | ISS | GO:0016477 | cell migration |
BP | ISS | GO:0098609 | cell-cell adhesion |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | IDA | GO:0005911 | cell-cell junction |
CC | HDA | GO:0005925 | focal adhesion |
CC | IEA | GO:0030027 | lamellipodium |
CC | IEA | GO:0030175 | filopodium |
CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
CC | HDA | GO:0070062 | extracellular exosome |
MF | IEA | GO:0005509 | calcium ion binding |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FAT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FAT1
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD498 | GW441756X | 1 |
iGMDRD662 | JQ-1 | 2 |
iGMDRD27 | WHI-P97 | 1 |
iGMDRD401 | Afatinib | 1 |
iGMDRD1002 | rTRAIL | 2 |
iGMDRD309 | 17AAG | 1 |
iGMDRD835 | BET inhibitor | 2 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FAT1