FAT1


Summary: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
FAT atypical cadherin 1MIM:600976Ensembl:ENSG00000083857HGNC:HGNC:3595PA1647199524q35.2

GO terms in FAT1


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0007015actin filament organization
BPTASGO:0007155cell adhesion
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPISSGO:0007163establishment or maintenance of cell polarity
BPTASGO:0007267cell-cell signaling
BPTASGO:0009653anatomical structure morphogenesis
BPISSGO:0016477cell migration
BPISSGO:0098609cell-cell adhesion
CCIDAGO:0005634nucleus
CCIDAGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0005911cell-cell junction
CCHDAGO:0005925focal adhesion
CCIEAGO:0030027lamellipodium
CCIEAGO:0030175filopodium
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: FAT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FAT1


DatabasePathway IDPathway Des.
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD498GW441756X1
iGMDRD662JQ-12
iGMDRD27WHI-P971
iGMDRD401Afatinib1
iGMDRD1002rTRAIL2
iGMDRD30917AAG1
iGMDRD835BET inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FAT1

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