MUC16


Summary: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mucin 16, cell surface associatedMIM:606154Ensembl:ENSG00000181143HGNC:HGNC:15582PA3131419p13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in MUC16


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005796Golgi lumen
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0019898extrinsic component of membrane
CCHDAGO:0031982vesicle
CCHDAGO:0070062extracellular exosome
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPNASGO:0007155cell adhesion
BPTASGO:0016266O-glycan processing
MFIPIGO:0005515protein binding

Gene expression in normal tissue: MUC16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MUC16


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083625Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
reactomeR-HSA-5083632Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
reactomeR-HSA-5083636Defective GALNT12 causes colorectal cancer 1 (CRCS1)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-913709O-linked glycosylation of mucins
reactomeR-HSA-977068Termination of O-glycan biosynthesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1
iGMDRD131Erlotinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MUC16

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