NCOR1
Summary: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor corepressor 1 | MIM:600849 | Ensembl:ENSG00000141027 | HGNC:HGNC:7672 | PA31477 | 17p12-p11.2 |
GO terms in NCOR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016580 | Sin3 complex |
| CC | IDA | GO:0016580 | Sin3 complex |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IDA | GO:0046329 | negative regulation of JNK cascade |
| BP | IMP | GO:0051225 | spindle assembly |
| BP | IMP | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter |
| BP | IMP | GO:0072368 | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter |
| BP | IMP | GO:1903799 | negative regulation of production of miRNAs involved in gene silencing by miRNA |
| BP | IC | GO:2000191 | regulation of fatty acid transport |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IMP | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | ISS | GO:0044212 | transcription regulatory region DNA binding |
| MF | IBA | GO:0046966 | thyroid hormone receptor binding |
Gene expression in normal tissue: NCOR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP34 | Ovarian Infertility Genes |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP61 | Notch Signaling Pathway |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_Notch | Notch |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368071 | NR1D1 (REV-ERBA) represses gene expression |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD775 | NCGC00346967-01 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD652 | UNC0638 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 2 |
| iGMDRD361 | 5Z-7-Oxozeaenol | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOR1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.