NRG1
Summary: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neuregulin 1 | MIM:142445 | Ensembl:ENSG00000157168 | HGNC:HGNC:7997 | PA31776 | 8p12 |
GO terms in NRG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | NAS | GO:0016020 | membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0030673 | axolemma |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0044297 | cell body |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001964 | startle response |
| BP | IEA | GO:0003161 | cardiac conduction system development |
| BP | IDA | GO:0003222 | ventricular trabecula myocardium morphogenesis |
| BP | TAS | GO:0007154 | cell communication |
| BP | IBA | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity |
| BP | IEA | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity |
| BP | IBA | GO:0007399 | nervous system development |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007416 | synapse assembly |
| BP | IEA | GO:0007422 | peripheral nervous system development |
| BP | IEA | GO:0007626 | locomotory behavior |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008366 | axon ensheathment |
| BP | IEA | GO:0009790 | embryo development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0014032 | neural crest cell development |
| BP | IEA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021781 | glial cell fate commitment |
| BP | IEA | GO:0021842 | chemorepulsion involved in interneuron migration from the subpallium to the cortex |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030879 | mammary gland development |
| BP | IEA | GO:0031643 | positive regulation of myelination |
| BP | IMP | GO:0032148 | activation of protein kinase B activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0038127 | ERBB signaling pathway |
| BP | IMP | GO:0038127 | ERBB signaling pathway |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IDA | GO:0038129 | ERBB3 signaling pathway |
| BP | TAS | GO:0042060 | wound healing |
| BP | IEA | GO:0042177 | negative regulation of protein catabolic process |
| BP | TAS | GO:0043496 | regulation of protein homodimerization activity |
| BP | IDA | GO:0043497 | regulation of protein heterodimerization activity |
| BP | IEA | GO:0045213 | neurotransmitter receptor metabolic process |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048513 | animal organ development |
| BP | IEA | GO:0048663 | neuron fate commitment |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0051048 | negative regulation of secretion |
| BP | ISS | GO:0051155 | positive regulation of striated muscle cell differentiation |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0055007 | cardiac muscle cell differentiation |
| BP | IDA | GO:0060379 | cardiac muscle cell myoblast differentiation |
| BP | IDA | GO:0060956 | endocardial cell differentiation |
| BP | IEA | GO:0060999 | positive regulation of dendritic spine development |
| BP | IEA | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| BP | IEA | GO:2000010 | positive regulation of protein localization to cell surface |
| BP | TAS | GO:2000145 | regulation of cell motility |
| BP | IEA | GO:2000727 | positive regulation of cardiac muscle cell differentiation |
| BP | IEA | GO:2001223 | negative regulation of neuron migration |
| MF | IDA | GO:0003712 | transcription coregulator activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | TAS | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005176 | ErbB-2 class receptor binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | NAS | GO:0008083 | growth factor activity |
| MF | IBA | GO:0030296 | protein tyrosine kinase activator activity |
| MF | NAS | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity |
| MF | NAS | GO:0030971 | receptor tyrosine kinase binding |
| MF | IDA | GO:0043125 | ErbB-3 class receptor binding |
| MF | IEA | GO:0045499 | chemorepellent activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
Gene expression in normal tissue: NRG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NRG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | erbb3pathway | neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250342 | PI3K events in ERBB4 signaling |
| reactome | R-HSA-1250347 | SHC1 events in ERBB4 signaling |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1306955 | GRB7 events in ERBB2 signaling |
| reactome | R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP673 | ErbB Signaling Pathway |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pid | glypican_1pathway | Glypican 1 network |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD817 | Anti-ERBB3 Agents | 1 |
| iGMDRD829 | AV-203 | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD288 | Carboplatin | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD972 | Patritumab | 1 |
| iGMDRD792 | Cetuximab | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NRG1
CLASSFICATION
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