PAFAH1B2


Summary: Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
platelet activating factor acetylhydrolase 1b catalytic subunit 2MIM:602508Ensembl:ENSG00000168092HGNC:HGNC:8575PA3290611q23.3

Gene Categories:

PHOSPHOLIPASE

GO terms in PAFAH1B2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity
MFTASGO:0004623phospholipase A2 activity
MFIPIGO:0005515protein binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0046982protein heterodimerization activity
MFIBAGO:0047179platelet-activating factor acetyltransferase activity
CCIDAGO:0001650fibrillar center
CCTASGO:0005576extracellular region
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0034774secretory granule lumen
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen
BPTASGO:0006629lipid metabolic process
BPIEAGO:0007283spermatogenesis
BPIBAGO:0007420brain development
BPIEAGO:0016042lipid catabolic process
BPIMPGO:0016239positive regulation of macroautophagy
BPTASGO:0043312neutrophil degranulation

Gene expression in normal tissue: PAFAH1B2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAFAH1B2


DatabasePathway IDPathway Des.
kegghsa00565Ether lipid metabolism - Homo sapiens (human)
pidlis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6811436COPI-independent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD297Austocystin D3
iGMDRD562Navitoclax3
iGMDRD61Kinetin riboside3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAFAH1B2

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