RGS9BP


Summary: The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
regulator of G protein signaling 9 binding proteinMIM:607814Ensembl:ENSG00000186326HGNC:HGNC:30304PA16240128019q13.11

GO terms in RGS9BP


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0001750photoreceptor outer segment
CCIEAGO:0016021integral component of membrane
BPIEAGO:0009968negative regulation of signal transduction
BPIEAGO:0050908detection of light stimulus involved in visual perception

Gene expression in normal tissue: RGS9BP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RGS9BP


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
pidcone_pathwayVisual signal transduction: Cones
pidrhodopsin_pathwayVisual signal transduction: Rods

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD491TAE-6841
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RGS9BP

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