RPS6KA4


Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein S6 kinase A4MIM:603606Ensembl:ENSG00000162302HGNC:HGNC:10433PA3484811q13.1

GO terms in RPS6KA4


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFNASGO:0004711ribosomal protein S6 kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
BPTASGO:0001818negative regulation of cytokine production
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006954inflammatory response
BPTASGO:0016572histone phosphorylation
BPTASGO:0032793positive regulation of CREB transcription factor activity
BPIMPGO:0033129positive regulation of histone phosphorylation
BPIMPGO:0035066positive regulation of histone acetylation
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIMPGO:0043987histone H3-S10 phosphorylation
BPIMPGO:0043988histone H3-S28 phosphorylation
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0070498interleukin-1-mediated signaling pathway
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol

Gene expression in normal tissue: RPS6KA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KA4


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-437239Recycling pathway of L1
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP585Interferon type I signaling pathways
piderbb1_downstream_pathwayErbB1 downstream signaling
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD634SCHEMBL26080413
iGMDRD353PD03259011
iGMDRD872BRD71373
iGMDRD103SN-383

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA4

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