S100A11
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| S100 calcium binding protein A11 | MIM:603114 | Ensembl:ENSG00000163191 | HGNC:HGNC:10488 | PA34900 | 1q21.3 |
GO terms in S100A11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | IDA | GO:0048306 | calcium-dependent protein binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008156 | negative regulation of DNA replication |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| CC | IDA | GO:0001726 | ruffle |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: S100A11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100A11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD134 | Sorafenib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A11
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