ST6GALNAC5
Summary: The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | MIM:610134 | Ensembl:ENSG00000117069 | HGNC:HGNC:19342 | PA134924485 | 1p31.1 |
GO terms in ST6GALNAC5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
| MF | TAS | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
| MF | IBA | GO:0008373 | sialyltransferase activity |
| MF | ISS | GO:0008373 | sialyltransferase activity |
| BP | ISS | GO:0006688 | glycosphingolipid biosynthetic process |
| BP | IBA | GO:0009311 | oligosaccharide metabolic process |
| BP | ISS | GO:0009312 | oligosaccharide biosynthetic process |
| BP | IBA | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IBA | GO:0097503 | sialylation |
| BP | IEA | GO:0097503 | sialylation |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: ST6GALNAC5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ST6GALNAC5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
| wikipathways | WP1424 | Globo Sphingolipid Metabolism |
| kegg | hsa00604 | Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ST6GALNAC5
CLASSFICATION
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