iGMDRD261


Canonical SMILES: COc1cccc2cc([nH]c12)c3nc([C@@H]4CC[C@H](CC4)C(=O)O)n5ncnc(N)c35

InChI: InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12,25H,5-8H2,1H3,(H,28,29)(H2,22,23,24)/t11-,12-

InChI Key: OMOBWMBJNNCUFO-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameOSI-027
Pubchem CID5172540
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

MTORC1/2

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

5reactome: Signal Transduction3kegg: MicroRNAs in cancer - Homo sapiens (human)3kegg: Pathways in cancer - Homo sapiens (human)3kegg: Glioma - Homo sapiens (human)3kegg: Prostate cancer - Homo sapiens (human)3wikipathways: Signaling Pathways in Glioblastoma3kegg: HTLV-I infection - Homo sapiens (human)3kegg: Melanoma - Homo sapiens (human)3kegg: Human papillomavirus infection - Homo sapiens (human)3reactome: Signaling by Receptor Tyrosine Kinases

Drug-gene GO enrichments

5MF: protein binding5MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding4CC: nucleus4MF: protein tyrosine kinase activity4BP: positive regulation of ERK1 and ERK2 cascade3CC: integral component of plasma membrane3CC: nucleoplasm3CC: cytoplasm3CC: membrane3BP: negative regulation of apoptotic process

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
9757 KMT2B 2
5159 PDGFRB 1
7301 TYRO3 1
1869 E2F1 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in OSI-027

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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