iGMDRD488


Canonical SMILES: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

InChI: InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+

InChI Key: SCELLOWTHJGVIC-BGYRXZFFSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameKU-60019
Pubchem CID15953900
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Drug-gene pathway enrichments

2reactome: G0 and Early G12reactome: Signaling by NOTCH2reactome: Signal Transduction2reactome: Transcription of E2F targets under negative control by DREAM complex2wikipathways: miR-targeted genes in lymphocytes - TarBase2pid: Direct p53 effectors2wikipathways: miR-targeted genes in muscle cell - TarBase2reactome: Cell Cycle2reactome: Pre-NOTCH Transcription and Translation2reactome: G1/S-Specific Transcription

Drug-gene GO enrichments

4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3CC: nucleoplasm3MF: protein heterodimerization activity2CC: nucleus2BP: cellular glucuronidation2CC: mitochondrion2BP: xenobiotic glucuronidation2MF: sequence-specific DNA binding2MF: protein binding2MF: glucuronosyltransferase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4170 MCL1 1
54658 UGT1A1 1
1869 E2F1 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorspyrvinium pamoatepyrvinium pamoatetipifarnib-P2tipifarnib-P2OSI-906 (Linsitinib)OSI-906 (Linsitinib)BMS-536924BMS-536924BIX01294BIX01294CHIR-99021CHIR-99021PNU-74654PNU-74654isoevodiamineisoevodiamineGW-843682XGW-843682XCompound.7d.cisCompound.7d.cisABT737ABT737Merck60Merck60PK-11195PK-11195fumonisin.B1fumonisin.B1LY 2183240LY 2183240Tyrphostin AG 1478Tyrphostin AG 1478zebularinezebularineSirolimusSirolimusMCL1MCL1SMER3SMER3BIRB-796BIRB-796importazoleimportazolePL.DIPL.DIAM-580AM-580NilotinibNilotinibfingolimodfingolimodBelinostatBelinostaterastinerastinIrinotecanIrinotecanUGT1A1UGT1A1SN-38SN-38BMS-754807BMS-754807SR-II-138ASR-II-138AcurcumincurcuminE2F1E2F1KU-60019KU-60019

Models in KU-60019

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(E2F1) protein MCLP PANCREAS undefined KU.60019 sensitivity in vitro
EXP(UGT1A) protein MCLP BREAST undefined KU.60019 resistance in vitro
EXP(CHK1_pS345) protein MCLP undefined PANCAN KU.60019 resistance in vitro
EXP(MCL1) protein MCLP undefined PANCAN KU.60019 resistance in vitro
Showing 1 to 4 of 4 rows

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