iGMDRD502

Canonical SMILES: CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F

InChI: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1

InChI Key: PDOQBOJDRPLBQU-QMMMGPOBSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameAZD1480
CHEMBLCHEMBL1231124
Pubchem CID16659800
DRUGBANK IDDB12588
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

JAK1JAK2

Drug-model tissue-cancer distribution: Bubble Plot

PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4THYROItissue: THYROI cancer: THYROID model num: 0THYROIDtissue: THYROID cancer: Medullary Thyroid Cancer (THME) model num: 1

Drug-gene pathway enrichments

2kegg: Pathways in cancer - Homo sapiens (human)2reactome: MAPK1/MAPK3 signaling2reactome: MAPK family signaling cascades2reactome: RAF/MAP kinase cascade2kegg: Central carbon metabolism in cancer - Homo sapiens (human)2pharmgkb: Sorafenib Pharmacodynamics2kegg: PI3K-Akt signaling pathway - Homo sapiens (human)2kegg: Jak-STAT signaling pathway - Homo sapiens (human)2wikipathways: PI3K-Akt Signaling Pathway2kegg: MicroRNAs in cancer - Homo sapiens (human)

Drug-gene GO enrichments

5CC: membrane5BP: negative regulation of apoptotic process4CC: cytoplasm4MF: protein tyrosine kinase activity4MF: transmembrane receptor protein tyrosine kinase activity4BP: positive regulation of ERK1 and ERK2 cascade4MF: protein binding3MF: platelet-derived growth factor binding3CC: plasma membrane3MF: platelet-derived growth factor beta-receptor activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4170 MCL1 1
5159 PDGFRB 1
1327 COX4I1 1
5979 RET 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in AZD1480

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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