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ASNS

Summary: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
asparagine synthetase (glutamine-hydrolyzing)	MIM:108370	Ensembl:ENSG00000070669	HGNC:HGNC:753	PA25052	7q21.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in ASNS

Term Type	Evidence Type	GO Term ID	GO Des.
MF	EXP	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
MF	IBA	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
MF	IDA	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0042803	protein homodimerization activity
MF	IEA	GO:0048037	cofactor binding
BP	IEA	GO:0001889	liver development
BP	IBA	GO:0006529	asparagine biosynthetic process
BP	IC	GO:0006529	asparagine biosynthetic process
BP	IDA	GO:0006529	asparagine biosynthetic process
BP	IEA	GO:0006541	glutamine metabolic process
BP	TAS	GO:0008652	cellular amino acid biosynthetic process
BP	IEA	GO:0009416	response to light stimulus
BP	IEA	GO:0009612	response to mechanical stimulus
BP	IEA	GO:0009636	response to toxic substance
BP	IEA	GO:0031427	response to methotrexate
BP	IEA	GO:0032354	response to follicle-stimulating hormone
BP	IEA	GO:0032870	cellular response to hormone stimulus
BP	TAS	GO:0036499	PERK-mediated unfolded protein response
BP	IDA	GO:0042149	cellular response to glucose starvation
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043200	response to amino acid
BP	IDA	GO:0045931	positive regulation of mitotic cell cycle
BP	IEA	GO:0070981	L-asparagine biosynthetic process
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol

Gene expression in normal tissue: ASNS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASNS

Database	Pathway ID	Pathway Des.
wikipathways	WP2753	ATF4 activates genes
wikipathways	WP3613	Photodynamic therapy-induced unfolded protein response
wikipathways	WP3925	Amino Acid metabolism
smpdb	SMP00009	Ammonia Recycling
smpdb	SMP00067	Aspartate Metabolism
smpdb	SMP00175	Canavan Disease
smpdb	SMP00192	Hypoacetylaspartia
humancyc	ASPARAGINE-BIOSYNTHESIS	asparagine biosynthesis
humancyc	GLUTAMINDEG-PWY	glutamine degradation/glutamate biosynthesis
kegg	hsa00250	Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-380994	ATF4 activates genes
reactome	R-HSA-381042	PERK regulates gene expression
reactome	R-HSA-381119	Unfolded Protein Response (UPR)
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-70614	Amino acid synthesis and interconversion (transamination)
reactome	R-HSA-71291	Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD48	Dexamethasone	1
iGMDRD377	Compound 1b	1
iGMDRD536	PLX-4720	1
iGMDRD1	Nicotin-Amide	1
iGMDRD99	Ethyl L-asparaginate	1
iGMDRD484	Pluripotin	1
iGMDRD605	AZD6482	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASNS

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.