ASNS

Summary: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameasparagine synthetase (glutamine-hydrolyzing)
OMIM IDMIM:108370
Ensembl IDEnsembl:ENSG00000070669
HGNC IDHGNC:HGNC:753
PHARMGKB IDPA25052
Map Location7q21.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in ASNS


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
MF IBA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
MF IDA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IBA GO:0042803 protein homodimerization activity
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Gene expression in normal tissue: ASNS

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 1

Gene-drug pathway distribution

undefined4PI3K/MTOR signaling1ERK MAPK signaling1Neuroactive ligand-receptor interaction1

Pathways in ASNS


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Database
Pathway ID
Pathway Des.
wikipathways WP2753 ATF4 activates genes
wikipathways WP3613 Photodynamic therapy-induced unfolded protein response
wikipathways WP3925 Amino Acid metabolism
smpdb SMP00009 Ammonia Recycling
smpdb SMP00067 Aspartate Metabolism
smpdb SMP00175 Canavan Disease
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD48 Dexamethasone 1
iGMDRD377 Compound 1b 1
iGMDRD536 PLX-4720 1
iGMDRD1 Nicotin-Amide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASNS

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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