Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].

protein tyrosine phosphatase, non-receptor type 1MIM:176885Ensembl:ENSG00000196396HGNC:HGNC:9642PA3398520q13.13

GO terms in PTPN1

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0004725protein tyrosine phosphatase activity
MFTASGO:0004725protein tyrosine phosphatase activity
MFIEAGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0030971receptor tyrosine kinase binding
MFHDAGO:0045296cadherin binding
MFIPIGO:0046875ephrin receptor binding
MFIEAGO:0051721protein phosphatase 2A binding
CCIDAGO:0005769early endosome
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005886plasma membrane
CCISSGO:0097443sorting endosome
CCIDAGO:0098554cytoplasmic side of endoplasmic reticulum membrane
BPIMPGO:0006470protein dephosphorylation
BPIEAGO:0007257activation of JUN kinase activity
BPIEAGO:0008286insulin receptor signaling pathway
BPIMPGO:0009966regulation of signal transduction
BPTASGO:0009968negative regulation of signal transduction
BPIDAGO:0030100regulation of endocytosis
BPISSGO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway
BPIDAGO:0030968endoplasmic reticulum unfolded protein response
BPIMPGO:0031532actin cytoskeleton reorganization
BPIMPGO:0033157regulation of intracellular protein transport
BPTASGO:0034620cellular response to unfolded protein
BPIDAGO:0035335peptidyl-tyrosine dephosphorylation
BPIMPGO:0035335peptidyl-tyrosine dephosphorylation
BPIMPGO:0035791platelet-derived growth factor receptor-beta signaling pathway
BPIEAGO:0036498IRE1-mediated unfolded protein response
BPIMPGO:0043407negative regulation of MAP kinase activity
BPNASGO:0046627negative regulation of insulin receptor signaling pathway
BPTASGO:0060338regulation of type I interferon-mediated signaling pathway
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPIDAGO:0061098positive regulation of protein tyrosine kinase activity
BPISSGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIMPGO:1902202regulation of hepatocyte growth factor receptor signaling pathway
BPIEAGO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPTASGO:1903896positive regulation of IRE1-mediated unfolded protein response
BPIDAGO:1903898negative regulation of PERK-mediated unfolded protein response
BPISSGO:1990264peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
BPIMPGO:2000646positive regulation of receptor catabolic process

Gene expression in normal tissue: PTPN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPN1

DatabasePathway IDPathway Des.
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidigf1_pathwayIGF1 pathway
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidncadherinpathwayN-cadherin signaling events
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidtcptp_pathwaySignaling events mediated by TCPTP
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6807004Negative regulation of MET activity
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849472PTK6 Down-Regulation
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-912694Regulation of IFNA signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-982772Growth hormone receptor signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD446LY 21832406
iGMDRD341Triacsin c3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPN1