PTPN1
Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, non-receptor type 1 | MIM:176885 | Ensembl:ENSG00000196396 | HGNC:HGNC:9642 | PA33985 | 20q13.13 |
GO terms in PTPN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IEA | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0030971 | receptor tyrosine kinase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | IEA | GO:0051721 | protein phosphatase 2A binding |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0097443 | sorting endosome |
| CC | IDA | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane |
| BP | IMP | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0007257 | activation of JUN kinase activity |
| BP | IEA | GO:0008286 | insulin receptor signaling pathway |
| BP | IMP | GO:0009966 | regulation of signal transduction |
| BP | TAS | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0030100 | regulation of endocytosis |
| BP | ISS | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IDA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IMP | GO:0033157 | regulation of intracellular protein transport |
| BP | TAS | GO:0034620 | cellular response to unfolded protein |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IMP | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IMP | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway |
| BP | IEA | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IMP | GO:0043407 | negative regulation of MAP kinase activity |
| BP | NAS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | TAS | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
| BP | TAS | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway |
| BP | IDA | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | ISS | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway |
| BP | IEA | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | TAS | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| BP | IDA | GO:1903898 | negative regulation of PERK-mediated unfolded protein response |
| BP | ISS | GO:1990264 | peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
| BP | IMP | GO:2000646 | positive regulation of receptor catabolic process |
Gene expression in normal tissue: PTPN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | igf1_pathway | IGF1 pathway |
| pid | insulin_pathway | Insulin Pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849472 | PTK6 Down-Regulation |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD705 | Nakiterpiosin | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPN1
CLASSFICATION
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