ANK3
Summary: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ankyrin 3 | MIM:600465 | Ensembl:ENSG00000151150 | HGNC:HGNC:494 | PA24800 | 10q21.2 |
GO terms in ANK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IMP | GO:0007009 | plasma membrane organization |
| BP | TAS | GO:0007016 | cytoskeletal anchoring at plasma membrane |
| BP | IEA | GO:0007165 | signal transduction |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | ISS | GO:0007528 | neuromuscular junction development |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010650 | positive regulation of cell communication by electrical coupling |
| BP | ISS | GO:0010765 | positive regulation of sodium ion transport |
| BP | ISS | GO:0010960 | magnesium ion homeostasis |
| BP | ISS | GO:0019228 | neuronal action potential |
| BP | ISS | GO:0034112 | positive regulation of homotypic cell-cell adhesion |
| BP | IMP | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | ISS | GO:0043266 | regulation of potassium ion transport |
| BP | IMP | GO:0045184 | establishment of protein localization |
| BP | ISS | GO:0045838 | positive regulation of membrane potential |
| BP | IBA | GO:0050808 | synapse organization |
| BP | ISS | GO:0071286 | cellular response to magnesium ion |
| BP | IMP | GO:0071709 | membrane assembly |
| BP | ISS | GO:0071709 | membrane assembly |
| BP | IBA | GO:0072659 | protein localization to plasma membrane |
| BP | IGI | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0072659 | protein localization to plasma membrane |
| BP | IGI | GO:0072660 | maintenance of protein location in plasma membrane |
| BP | ISS | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | IBA | GO:0099612 | protein localization to axon |
| BP | ISS | GO:1900827 | positive regulation of membrane depolarization during cardiac muscle cell action potential |
| BP | ISS | GO:1902260 | negative regulation of delayed rectifier potassium channel activity |
| BP | ISS | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity |
| BP | ISS | GO:2001259 | positive regulation of cation channel activity |
| CC | IEA | GO:0005764 | lysosome |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IDA | GO:0009925 | basal plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
| CC | IBA | GO:0014704 | intercalated disc |
| CC | ISS | GO:0014704 | intercalated disc |
| CC | ISS | GO:0014731 | spectrin-associated cytoskeleton |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016328 | lateral plasma membrane |
| CC | ISS | GO:0016529 | sarcoplasmic reticulum |
| CC | ISS | GO:0030018 | Z disc |
| CC | ISS | GO:0030315 | T-tubule |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0031594 | neuromuscular junction |
| CC | IBA | GO:0033268 | node of Ranvier |
| CC | ISS | GO:0033268 | node of Ranvier |
| CC | IBA | GO:0033270 | paranode region of axon |
| CC | IDA | GO:0042383 | sarcolemma |
| CC | ISS | GO:0043005 | neuron projection |
| CC | TAS | GO:0043034 | costamere |
| CC | IBA | GO:0043194 | axon initial segment |
| CC | IDA | GO:0043194 | axon initial segment |
| CC | ISS | GO:0043194 | axon initial segment |
| CC | IBA | GO:0045202 | synapse |
| CC | ISS | GO:0045211 | postsynaptic membrane |
| MF | IMP | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008092 | cytoskeletal protein binding |
| MF | ISS | GO:0030507 | spectrin binding |
| MF | ISS | GO:0030674 | protein binding, bridging |
| MF | IBA | GO:0044325 | ion channel binding |
| MF | ISS | GO:0044325 | ion channel binding |
| MF | ISS | GO:0045296 | cadherin binding |
Gene expression in normal tissue: ANK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445095 | Interaction between L1 and Ankyrins |
| reactome | R-HSA-445095 | Interaction between L1 and Ankyrins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD322 | FK 866 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANK3
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