ASNS


Summary: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
asparagine synthetase (glutamine-hydrolyzing)MIM:108370Ensembl:ENSG00000070669HGNC:HGNC:753PA250527q21.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in ASNS


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004066asparagine synthase (glutamine-hydrolyzing) activity
MFIBAGO:0004066asparagine synthase (glutamine-hydrolyzing) activity
MFIDAGO:0004066asparagine synthase (glutamine-hydrolyzing) activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0042803protein homodimerization activity
MFIEAGO:0048037cofactor binding
BPIEAGO:0001889liver development
BPIBAGO:0006529asparagine biosynthetic process
BPICGO:0006529asparagine biosynthetic process
BPIDAGO:0006529asparagine biosynthetic process
BPIEAGO:0006541glutamine metabolic process
BPTASGO:0008652cellular amino acid biosynthetic process
BPIEAGO:0009416response to light stimulus
BPIEAGO:0009612response to mechanical stimulus
BPIEAGO:0009636response to toxic substance
BPIEAGO:0031427response to methotrexate
BPIEAGO:0032354response to follicle-stimulating hormone
BPIEAGO:0032870cellular response to hormone stimulus
BPTASGO:0036499PERK-mediated unfolded protein response
BPIDAGO:0042149cellular response to glucose starvation
BPIMPGO:0043066negative regulation of apoptotic process
BPIEAGO:0043200response to amino acid
BPIDAGO:0045931positive regulation of mitotic cell cycle
BPIEAGO:0070981L-asparagine biosynthetic process
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol

Gene expression in normal tissue: ASNS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASNS


DatabasePathway IDPathway Des.
wikipathwaysWP2753ATF4 activates genes
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP3925Amino Acid metabolism
smpdbSMP00009Ammonia Recycling
smpdbSMP00067Aspartate Metabolism
smpdbSMP00175Canavan Disease
smpdbSMP00192Hypoacetylaspartia
humancycASPARAGINE-BIOSYNTHESISasparagine biosynthesis
humancycGLUTAMINDEG-PWYglutamine degradation/glutamate biosynthesis
kegghsa00250Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-380994ATF4 activates genes
reactomeR-HSA-381042PERK regulates gene expression
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-70614Amino acid synthesis and interconversion (transamination)
reactomeR-HSA-71291Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD48Dexamethasone1
iGMDRD377Compound 1b1
iGMDRD536PLX-47201
iGMDRD1Nicotin-Amide1
iGMDRD99Ethyl L-asparaginate1
iGMDRD484Pluripotin1
iGMDRD605AZD64821

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASNS

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