ASNS
Summary: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
asparagine synthetase (glutamine-hydrolyzing) | MIM:108370 | Ensembl:ENSG00000070669 | HGNC:HGNC:753 | PA25052 | 7q21.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in ASNS
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | EXP | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity |
MF | IBA | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity |
MF | IDA | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IBA | GO:0042803 | protein homodimerization activity |
MF | IEA | GO:0048037 | cofactor binding |
BP | IEA | GO:0001889 | liver development |
BP | IBA | GO:0006529 | asparagine biosynthetic process |
BP | IC | GO:0006529 | asparagine biosynthetic process |
BP | IDA | GO:0006529 | asparagine biosynthetic process |
BP | IEA | GO:0006541 | glutamine metabolic process |
BP | TAS | GO:0008652 | cellular amino acid biosynthetic process |
BP | IEA | GO:0009416 | response to light stimulus |
BP | IEA | GO:0009612 | response to mechanical stimulus |
BP | IEA | GO:0009636 | response to toxic substance |
BP | IEA | GO:0031427 | response to methotrexate |
BP | IEA | GO:0032354 | response to follicle-stimulating hormone |
BP | IEA | GO:0032870 | cellular response to hormone stimulus |
BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
BP | IDA | GO:0042149 | cellular response to glucose starvation |
BP | IMP | GO:0043066 | negative regulation of apoptotic process |
BP | IEA | GO:0043200 | response to amino acid |
BP | IDA | GO:0045931 | positive regulation of mitotic cell cycle |
BP | IEA | GO:0070981 | L-asparagine biosynthetic process |
CC | IBA | GO:0005829 | cytosol |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: ASNS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ASNS
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2753 | ATF4 activates genes |
wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
wikipathways | WP3925 | Amino Acid metabolism |
smpdb | SMP00009 | Ammonia Recycling |
smpdb | SMP00067 | Aspartate Metabolism |
smpdb | SMP00175 | Canavan Disease |
smpdb | SMP00192 | Hypoacetylaspartia |
humancyc | ASPARAGINE-BIOSYNTHESIS | asparagine biosynthesis |
humancyc | GLUTAMINDEG-PWY | glutamine degradation/glutamate biosynthesis |
kegg | hsa00250 | Alanine, aspartate and glutamate metabolism - Homo sapiens (human) |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-380994 | ATF4 activates genes |
reactome | R-HSA-381042 | PERK regulates gene expression |
reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-70614 | Amino acid synthesis and interconversion (transamination) |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD48 | Dexamethasone | 1 |
iGMDRD377 | Compound 1b | 1 |
iGMDRD536 | PLX-4720 | 1 |
iGMDRD1 | Nicotin-Amide | 1 |
iGMDRD99 | Ethyl L-asparaginate | 1 |
iGMDRD484 | Pluripotin | 1 |
iGMDRD605 | AZD6482 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ASNS