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BID

Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
BH3 interacting domain death agonist	MIM:601997	Ensembl:ENSG00000015475	HGNC:HGNC:1050	PA25353	22q11.21

Gene Categories:

PROTEASE TUMOR SUPPRESSOR

GO terms in BID

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0001836	release of cytochrome c from mitochondria
BP	IEA	GO:0006626	protein targeting to mitochondrion
BP	IEA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	TAS	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
BP	TAS	GO:0008637	apoptotic mitochondrial changes
BP	IEA	GO:0010918	positive regulation of mitochondrial membrane potential
BP	IDA	GO:0032461	positive regulation of protein oligomerization
BP	IDA	GO:0032464	positive regulation of protein homooligomerization
BP	IEA	GO:0042127	regulation of cell proliferation
BP	TAS	GO:0042770	signal transduction in response to DNA damage
BP	IEA	GO:0042775	mitochondrial ATP synthesis coupled electron transport
BP	TAS	GO:0042981	regulation of apoptotic process
BP	IMP	GO:0043065	positive regulation of apoptotic process
BP	TAS	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0051260	protein homooligomerization
BP	TAS	GO:0051402	neuron apoptotic process
BP	IDA	GO:0090150	establishment of protein localization to membrane
BP	IGI	GO:0090200	positive regulation of release of cytochrome c from mitochondria
BP	IMP	GO:0090200	positive regulation of release of cytochrome c from mitochondria
BP	IEA	GO:0097284	hepatocyte apoptotic process
BP	IEA	GO:0097345	mitochondrial outer membrane permeabilization
BP	TAS	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BP	TAS	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BP	IEA	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
BP	IEA	GO:2000045	regulation of G1/S transition of mitotic cell cycle
BP	IEA	GO:2000271	positive regulation of fibroblast apoptotic process
BP	IMP	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
BP	IMP	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
BP	TAS	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
CC	TAS	GO:0005739	mitochondrion
CC	TAS	GO:0005741	mitochondrial outer membrane
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0016020	membrane
CC	IEA	GO:0032592	integral component of mitochondrial membrane
MF	TAS	GO:0005123	death receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0031625	ubiquitin protein ligase binding
MF	IEA	GO:0046982	protein heterodimerization activity

Gene expression in normal tissue: BID

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BID

Database	Pathway ID	Pathway Des.
wikipathways	WP1530	miRNA Regulation of DNA Damage Response
wikipathways	WP1742	TP53 Network
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP2059	Alzheimers Disease
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2447	Amyotrophic lateral sclerosis (ALS)
wikipathways	WP2507	Nanomaterial induced apoptosis
wikipathways	WP254	Apoptosis
wikipathways	WP3611	Photodynamic therapy-induced AP-1 survival signaling.
wikipathways	WP3614	Photodynamic therapy-induced HIF-1 survival signaling
wikipathways	WP3639	Apoptotic Signaling Pathway
wikipathways	WP3802	TP53 Regulates Transcription of Cell Death Genes
wikipathways	WP384	Apoptosis Modulation by HSP70
wikipathways	WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathways	WP3982	miRNA regulation of p53 pathway in prostate cancer
wikipathways	WP707	DNA Damage Response
pid	atm_pathway	ATM pathway
pid	caspase_pathway	Caspase Cascade in Apoptosis
pid	ceramide_pathway	Ceramide signaling pathway
pid	faspathway	FAS (CD95) signaling pathway
pid	hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
pid	p53downstreampathway	Direct p53 effectors
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04115	p53 signaling pathway - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04215	Apoptosis - multiple species - Homo sapiens (human)
kegg	hsa04217	Necroptosis - Homo sapiens (human)
kegg	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa05010	Alzheimer,s disease - Homo sapiens (human)
kegg	hsa05014	Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05416	Viral myocarditis - Homo sapiens (human)
netpath	Pathway_TNFalpha	TNFalpha
biocarta	chemicalpathway	apoptotic signaling in response to dna damage
biocarta	deathpathway	induction of apoptosis through dr3 and dr4/5 death receptors
biocarta	hivnefpathway	hiv-1 nef: negative effector of fas and tnf
biocarta	mitochondriapathway	role of mitochondria in apoptotic signaling
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-109606	Intrinsic Pathway for Apoptosis
reactome	R-HSA-111447	Activation of BAD and translocation to mitochondria
reactome	R-HSA-111452	Activation and oligomerization of BAK protein
reactome	R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactome	R-HSA-114294	Activation, translocation and oligomerization of BAX
reactome	R-HSA-114452	Activation of BH3-only proteins
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-5357801	Programmed Cell Death
reactome	R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes
reactome	R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD885	Compound 110	3
iGMDRD424	Tamatinib	2
iGMDRD1	Nicotin-Amide	1
iGMDRD33	Entinostat	1
iGMDRD262	KU-55933	1
iGMDRD882	CIL41	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BID

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DATATYPES

CLASSFICATION

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