Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008].

BH3 interacting domain death agonistMIM:601997Ensembl:ENSG00000015475HGNC:HGNC:1050PA2535322q11.21

Gene Categories:


GO terms in BID

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001836release of cytochrome c from mitochondria
BPIEAGO:0006626protein targeting to mitochondrion
BPIEAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:0008637apoptotic mitochondrial changes
BPIEAGO:0010918positive regulation of mitochondrial membrane potential
BPIDAGO:0032461positive regulation of protein oligomerization
BPIDAGO:0032464positive regulation of protein homooligomerization
BPIEAGO:0042127regulation of cell proliferation
BPTASGO:0042770signal transduction in response to DNA damage
BPIEAGO:0042775mitochondrial ATP synthesis coupled electron transport
BPTASGO:0042981regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIEAGO:0051260protein homooligomerization
BPTASGO:0051402neuron apoptotic process
BPIDAGO:0090150establishment of protein localization to membrane
BPIGIGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIEAGO:0097284hepatocyte apoptotic process
BPIEAGO:0097345mitochondrial outer membrane permeabilization
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPTASGO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BPIEAGO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:2000045regulation of G1/S transition of mitotic cell cycle
BPIEAGO:2000271positive regulation of fibroblast apoptotic process
BPIMPGO:2001238positive regulation of extrinsic apoptotic signaling pathway
BPIMPGO:2001244positive regulation of intrinsic apoptotic signaling pathway
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
CCTASGO:0005741mitochondrial outer membrane
CCIEAGO:0032592integral component of mitochondrial membrane
MFTASGO:0005123death receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0031625ubiquitin protein ligase binding
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: BID

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BID

DatabasePathway IDPathway Des.
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1742TP53 Network
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP707DNA Damage Response
pidatm_pathwayATM pathway
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidfaspathwayFAS (CD95) signaling pathway
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp53downstreampathwayDirect p53 effectors
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-111452Activation and oligomerization of BAK protein
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-114294Activation, translocation and oligomerization of BAX
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75108Activation, myristolyation of BID and translocation to mitochondria

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BID