CUL3
Summary: This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cullin 3 | MIM:603136 | Ensembl:ENSG00000036257 | HGNC:HGNC:2553 | PA27049 | 2q36.2 |
GO terms in CUL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005112 | Notch binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030332 | cyclin binding |
| MF | IDA | GO:0031208 | POZ domain binding |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0001831 | trophectodermal cellular morphogenesis |
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0006513 | protein monoubiquitination |
| BP | IDA | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IMP | GO:0007080 | mitotic metaphase plate congression |
| BP | ISS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007369 | gastrulation |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IMP | GO:0016477 | cell migration |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | ISS | GO:0017145 | stem cell division |
| BP | IEA | GO:0030030 | cell projection organization |
| BP | IDA | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IGI | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IGI | GO:0031648 | protein destabilization |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IMP | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | ISS | GO:0040016 | embryonic cleavage |
| BP | IMP | GO:0043149 | stress fiber assembly |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IEA | GO:0044346 | fibroblast apoptotic process |
| BP | IMP | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| BP | IMP | GO:0048208 | COPII vesicle coating |
| BP | IDA | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system |
| BP | IEA | GO:0072576 | liver morphogenesis |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0097193 | intrinsic apoptotic signaling pathway |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005827 | polar microtubule |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0031461 | cullin-RING ubiquitin ligase complex |
| CC | IDA | GO:0031463 | Cul3-RING ubiquitin ligase complex |
| CC | IDA | GO:0036126 | sperm flagellum |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CUL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CUL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4641258 | Degradation of DVL |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5658442 | Regulation of RAS by GAPs |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD669 | PDK1 inhibitor | 1 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD441 | TW 37 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CUL3
CLASSFICATION
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