FGF1
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor 1 | MIM:131220 | Ensembl:ENSG00000113578 | HGNC:HGNC:3665 | PA28105 | 5q31.3 |
GO terms in FGF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005104 | fibroblast growth factor receptor binding |
| MF | IPI | GO:0005104 | fibroblast growth factor receptor binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0008201 | heparin binding |
| MF | IMP | GO:0008201 | heparin binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001759 | organ induction |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IGI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IMP | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IPI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030324 | lung development |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IDA | GO:0045542 | positive regulation of cholesterol biosynthetic process |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IDA | GO:0051781 | positive regulation of cell division |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0060681 | branch elongation involved in ureteric bud branching |
| BP | IDA | GO:0072163 | mesonephric epithelium development |
| BP | IMP | GO:1901509 | regulation of endothelial tube morphogenesis |
| BP | IDA | GO:1902533 | positive regulation of intracellular signal transduction |
| BP | IMP | GO:1903672 | positive regulation of sprouting angiogenesis |
| BP | IDA | GO:2000544 | regulation of endothelial cell chemotaxis to fibroblast growth factor |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005938 | cell cortex |
Gene expression in normal tissue: FGF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | fgf_pathway | FGF signaling pathway |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839122 | Signaling by activated point mutants of FGFR1 |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-1839126 | FGFR2 mutant receptor activation |
| reactome | R-HSA-1839130 | Signaling by activated point mutants of FGFR3 |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-190239 | FGFR3 ligand binding and activation |
| reactome | R-HSA-190241 | FGFR2 ligand binding and activation |
| reactome | R-HSA-190242 | FGFR1 ligand binding and activation |
| reactome | R-HSA-190322 | FGFR4 ligand binding and activation |
| reactome | R-HSA-190370 | FGFR1b ligand binding and activation |
| reactome | R-HSA-190371 | FGFR3b ligand binding and activation |
| reactome | R-HSA-190372 | FGFR3c ligand binding and activation |
| reactome | R-HSA-190373 | FGFR1c ligand binding and activation |
| reactome | R-HSA-190375 | FGFR2c ligand binding and activation |
| reactome | R-HSA-190377 | FGFR2b ligand binding and activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2033514 | FGFR3 mutant receptor activation |
| reactome | R-HSA-2033519 | Activated point mutants of FGFR2 |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 |
| reactome | R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 |
| reactome | R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 |
| reactome | R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654688 | SHC-mediated cascade:FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654693 | FRS-mediated FGFR1 signaling |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654699 | SHC-mediated cascade:FGFR2 |
| reactome | R-HSA-5654700 | FRS-mediated FGFR2 signaling |
| reactome | R-HSA-5654704 | SHC-mediated cascade:FGFR3 |
| reactome | R-HSA-5654706 | FRS-mediated FGFR3 signaling |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654712 | FRS-mediated FGFR4 signaling |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654719 | SHC-mediated cascade:FGFR4 |
| reactome | R-HSA-5654720 | PI-3K cascade:FGFR4 |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8851708 | Signaling by FGFR2 IIIa TM |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD23 | Gossypol | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.