Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

forkhead box M1MIM:602341Ensembl:ENSG00000111206HGNC:HGNC:3818PA2823612p13.33

GO terms in FOXM1

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
BPIDAGO:0000086G2/M transition of mitotic cell cycle
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006281DNA repair
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BPIMPGO:0008284positive regulation of cell proliferation
BPIMPGO:0032873negative regulation of stress-activated MAPK cascade
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046578regulation of Ras protein signal transduction
BPTASGO:0051726regulation of cell cycle
BPIMPGO:0071156regulation of cell cycle arrest
BPIMPGO:0090344negative regulation of cell aging
BPIMPGO:2000377regulation of reactive oxygen species metabolic process
BPIMPGO:2000781positive regulation of double-strand break repair

Gene expression in normal tissue: FOXM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXM1

DatabasePathway IDPathway Des.
pidfoxm1pathwayFOXM1 transcription factor network
kegghsa04218Cellular senescence - Homo sapiens (human)
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXM1