GNRH1
Summary: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gonadotropin releasing hormone 1 | MIM:152760 | Ensembl:ENSG00000147437 | HGNC:HGNC:4419 | PA28798 | 8p21.2 |
GO terms in GNRH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005798 | Golgi-associated vesicle |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0043679 | axon terminus |
| CC | IEA | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane |
| CC | IEA | GO:1990008 | neurosecretory vesicle |
| BP | IBA | GO:0000003 | reproduction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007568 | aging |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0030238 | male sex determination |
| BP | IEA | GO:0031960 | response to corticosteroid |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0033087 | negative regulation of immature T cell proliferation |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IEA | GO:0034695 | response to prostaglandin E |
| BP | IEA | GO:0035864 | response to potassium ion |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0044849 | estrous cycle |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:1990637 | response to prolactin |
| BP | IEA | GO:2000354 | regulation of ovarian follicle development |
| BP | IEA | GO:2001223 | negative regulation of neuron migration |
| MF | TAS | GO:0005179 | hormone activity |
| MF | IBA | GO:0005183 | gonadotropin hormone-releasing hormone activity |
| MF | IEA | GO:0005183 | gonadotropin hormone-releasing hormone activity |
| MF | IBA | GO:0031530 | gonadotropin-releasing hormone receptor binding |
Gene expression in normal tissue: GNRH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GNRH1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| wikipathways | WP4194 | Hormonal control of Pubertal Growth Spurt |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375281 | Hormone ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GNRH1
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