IL7R
Summary: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 7 receptor | MIM:146661 | Ensembl:ENSG00000168685 | HGNC:HGNC:6024 | PA29840 | 5p13.2 |
GO terms in IL7R
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003823 | antigen binding |
| MF | IDA | GO:0004896 | cytokine receptor activity |
| MF | TAS | GO:0004917 | interleukin-7 receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| BP | TAS | GO:0000018 | regulation of DNA recombination |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| BP | IEA | GO:0002377 | immunoglobulin production |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008361 | regulation of cell size |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0030217 | T cell differentiation |
| BP | IEA | GO:0033089 | positive regulation of T cell differentiation in thymus |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | IEA | GO:0042100 | B cell proliferation |
| BP | IEA | GO:0048535 | lymph node development |
| BP | IEA | GO:0048872 | homeostasis of number of cells |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IEA | GO:0070233 | negative regulation of T cell apoptotic process |
| BP | IDA | GO:1904894 | positive regulation of STAT cascade |
Gene expression in normal tissue: IL7R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL7R
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_KitReceptor | KitReceptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD574 | Ruxolitinib | 8 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD949 | mTOR inhibitor | 3 |
| iGMDRD541 | SNX-2112 (PF-04928473) | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD950 | mTOR inhibitor (in SH2B3 deleted) | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL7R
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.