KLF6


Summary: This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Kruppel like factor 6MIM:602053Ensembl:ENSG00000067082HGNC:HGNC:2235PA2675110p15.2

GO terms in KLF6


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003690double-stranded DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0001650fibrillar center
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIBAGO:0019221cytokine-mediated signaling pathway
BPNASGO:0030183B cell differentiation
BPTASGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: KLF6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLF6


DatabasePathway IDPathway Des.
wikipathwaysWP236Adipogenesis
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP366TGF-beta Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD187BRD98763
iGMDRD451Serdemetan3
iGMDRD513BML-2593
iGMDRD100Zebularine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLF6

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