Summary: The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

MAF bZIP transcription factorMIM:177075Ensembl:ENSG00000178573HGNC:HGNC:6776PA3053416q23.2

GO terms in MAF

Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0043565sequence-specific DNA binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001816cytokine production
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0032330regulation of chondrocyte differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048468cell development
BPIEAGO:0048839inner ear development
BPIBAGO:0070306lens fiber cell differentiation

Gene expression in normal tissue: MAF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAF

DatabasePathway IDPathway Des.
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP3945TYROBP Causal Network
pidap1_pathwayAP-1 transcription factor network
pidcmyb_pathwayC-MYB transcription factor network
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAF