MAFB
Summary: The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MAF bZIP transcription factor B | MIM:608968 | Ensembl:ENSG00000204103 | HGNC:HGNC:6408 | PA30535 | 20q12 |
GO terms in MAFB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005667 | transcription factor complex |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007379 | segment specification |
| BP | TAS | GO:0007423 | sensory organ development |
| BP | IEA | GO:0007585 | respiratory gaseous exchange |
| BP | IEA | GO:0021571 | rhombomere 5 development |
| BP | IEA | GO:0021572 | rhombomere 6 development |
| BP | ISS | GO:0021599 | abducens nerve formation |
| BP | IEA | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0035284 | brain segmentation |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IDA | GO:0045647 | negative regulation of erythrocyte differentiation |
| BP | ISS | GO:0045671 | negative regulation of osteoclast differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048538 | thymus development |
Gene expression in normal tissue: MAFB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAFB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| wikipathways | WP2858 | Ectoderm Differentiation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAFB
CLASSFICATION
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