MCM3


Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
minichromosome maintenance complex component 3MIM:602693Ensembl:ENSG00000112118HGNC:HGNC:6945PA306916p12.2

GO terms in MCM3


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0006260DNA replication
BPIEAGO:0006270DNA replication initiation
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005658alpha DNA polymerase:primase complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005813centrosome
CCHDAGO:0016020membrane
CCIDAGO:0042555MCM complex
CCIDAGO:0048471perinuclear region of cytoplasm
MFIEAGO:0003677DNA binding
MFIEAGO:0004386helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: MCM3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCM3


DatabasePathway IDPathway Des.
pide2f_pathwayE2F transcription factor network
kegghsa03030DNA replication - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
wikipathwaysWP179Cell Cycle
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP466DNA Replication
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-176187Activation of ATR in response to replication stress
reactomeR-HSA-176974Unwinding of DNA
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
biocartamcmpathwaycdk regulation of dna replication

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD63Camptothecin1
iGMDRD434BMS-5369241
iGMDRD42Vorinostat1
iGMDRD412VX-7021

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCM3

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