FOXM1
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box M1 | MIM:602341 | Ensembl:ENSG00000111206 | HGNC:HGNC:3818 | PA28236 | 12p13.33 |
GO terms in FOXM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046578 | regulation of Ras protein signal transduction |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:0071156 | regulation of cell cycle arrest |
| BP | IMP | GO:0090344 | negative regulation of cell aging |
| BP | IMP | GO:2000377 | regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2000781 | positive regulation of double-strand break repair |
| CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: FOXM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | foxm1pathway | FOXM1 transcription factor network |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD773 | CBB1007 | 1 |
| iGMDRD456 | Crizotinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXM1
CLASSFICATION
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