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NCKIPSD

Summary: The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameNCK interacting protein with SH3 domain OMIM IDMIM:606671 Ensembl IDEnsembl:ENSG00000213672 HGNC IDHGNC:HGNC:15486 PHARMGKB IDPA134872724 Map Location3p21.31

GO terms in NCKIPSD

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0006607	NLS-bearing protein import into nucleus
BP	NAS	GO:0007010	cytoskeleton organization
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0010976	positive regulation of neuron projection development
BP	TAS	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
CC	TAS	GO:0005829	cytosol

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Gene expression in normal tissue: NCKIPSD

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCKIPSD

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD446	LY 2183240	3
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD61	Kinetin riboside	3
iGMDRD280	CYTOCHALASIN B	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCKIPSD

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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