PARK7


Summary: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Parkinsonism associated deglycaseMIM:602533Ensembl:ENSG00000116288HGNC:HGNC:16369PA329461p36.23

GO terms in PARK7


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000785chromatin
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIMPGO:0005739mitochondrion
CCIDAGO:0005747mitochondrial respiratory chain complex I
CCIEAGO:0005758mitochondrial intermembrane space
CCIEAGO:0005759mitochondrial matrix
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIMPGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCHDAGO:0005913cell-cell adherens junction
CCIDAGO:0016605PML body
CCISSGO:0030424axon
CCIEAGO:0044297cell body
CCIEAGO:0045121membrane raft
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIEAGO:0098793presynapse
BPIGIGO:0001933negative regulation of protein phosphorylation
BPISSGO:0002866positive regulation of acute inflammatory response to antigenic stimulus
BPIDAGO:0006281DNA repair
BPIGIGO:0006469negative regulation of protein kinase activity
BPIEAGO:0006508proteolysis
BPIDAGO:0006517protein deglycosylation
BPIDAGO:0006517protein deglycosylation
BPIMPGO:0006517protein deglycosylation
BPIEAGO:0006914autophagy
BPIEAGO:0006954inflammatory response
BPISSGO:0007005mitochondrion organization
BPTASGO:0007265Ras protein signal transduction
BPIEAGO:0007338single fertilization
BPIEAGO:0008344adult locomotory behavior
BPIDAGO:0009438methylglyoxal metabolic process
BPIDAGO:0009438methylglyoxal metabolic process
BPIMPGO:0010273detoxification of copper ion
BPTASGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPIEAGO:0018323enzyme active site formation via L-cysteine sulfinic acid
BPIDAGO:0019249lactate biosynthetic process
BPISSGO:0030073insulin secretion
BPIDAGO:0031397negative regulation of protein ubiquitination
BPIDAGO:0032091negative regulation of protein binding
BPIGIGO:0032091negative regulation of protein binding
BPIMPGO:0032091negative regulation of protein binding
BPICGO:0032148activation of protein kinase B activity
BPIDAGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0032757positive regulation of interleukin-8 production
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0033234negative regulation of protein sumoylation
BPISSGO:0033864positive regulation of NAD(P)H oxidase activity
BPIDAGO:0034599cellular response to oxidative stress
BPIMPGO:0034599cellular response to oxidative stress
BPIDAGO:0036471cellular response to glyoxal
BPIDAGO:0036526peptidyl-cysteine deglycation
BPIDAGO:0036527peptidyl-arginine deglycation
BPIDAGO:0036528peptidyl-lysine deglycation
BPIBAGO:0036529protein deglycation, glyoxal removal
BPIDAGO:0036529protein deglycation, glyoxal removal
BPIDAGO:0036530protein deglycation, methylglyoxal removal
BPIDAGO:0036530protein deglycation, methylglyoxal removal
BPIDAGO:0036531glutathione deglycation
BPISSGO:0042593glucose homeostasis
BPIDAGO:0042743hydrogen peroxide metabolic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043523regulation of neuron apoptotic process
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPIMPGO:0045560regulation of TRAIL receptor biosynthetic process
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046295glycolate biosynthetic process
BPIGIGO:0046826negative regulation of protein export from nucleus
BPISSGO:0050727regulation of inflammatory response
BPIMPGO:0050787detoxification of mercury ion
BPIDAGO:0050821protein stabilization
BPIMPGO:0050821protein stabilization
BPIMPGO:0051091positive regulation of DNA-binding transcription factor activity
BPTASGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051444negative regulation of ubiquitin-protein transferase activity
BPIEAGO:0051583dopamine uptake involved in synaptic transmission
BPIMPGO:0051881regulation of mitochondrial membrane potential
BPICGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0051899membrane depolarization
BPIEAGO:0060081membrane hyperpolarization
BPIDAGO:0060548negative regulation of cell death
BPIDAGO:0060765regulation of androgen receptor signaling pathway
BPIDAGO:0070301cellular response to hydrogen peroxide
BPIDAGO:0090073positive regulation of protein homodimerization activity
BPIEAGO:0098869cellular oxidant detoxification
BPIDAGO:0106044guanine deglycation
BPIDAGO:0106045guanine deglycation, methylglyoxal removal
BPIBAGO:0106046guanine deglycation, glyoxal removal
BPIDAGO:0106046guanine deglycation, glyoxal removal
BPIDAGO:1900182positive regulation of protein localization to nucleus
BPIMPGO:1900182positive regulation of protein localization to nucleus
BPIDAGO:1901215negative regulation of neuron death
BPIDAGO:1901671positive regulation of superoxide dismutase activity
BPIDAGO:1901984negative regulation of protein acetylation
BPIEAGO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
BPIGIGO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPTASGO:1902903regulation of supramolecular fiber organization
BPIMPGO:1902958positive regulation of mitochondrial electron transport, NADH to ubiquinone
BPICGO:1903073negative regulation of death-inducing signaling complex assembly
BPIDAGO:1903094negative regulation of protein K48-linked deubiquitination
BPIMPGO:1903122negative regulation of TRAIL-activated apoptotic signaling pathway
BPIDAGO:1903168positive regulation of pyrroline-5-carboxylate reductase activity
BPIDAGO:1903178positive regulation of tyrosine 3-monooxygenase activity
BPICGO:1903181positive regulation of dopamine biosynthetic process
BPIDAGO:1903181positive regulation of dopamine biosynthetic process
BPIDAGO:1903189glyoxal metabolic process
BPIMPGO:1903197positive regulation of L-dopa biosynthetic process
BPIDAGO:1903200positive regulation of L-dopa decarboxylase activity
BPIDAGO:1903202negative regulation of oxidative stress-induced cell death
BPIMPGO:1903206negative regulation of hydrogen peroxide-induced cell death
BPIDAGO:1903208negative regulation of hydrogen peroxide-induced neuron death
BPIDAGO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
BPIGIGO:1903384negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
BPISSGO:1903427negative regulation of reactive oxygen species biosynthetic process
BPIEAGO:1903428positive regulation of reactive oxygen species biosynthetic process
BPNASGO:1903599positive regulation of autophagy of mitochondrion
BPIDAGO:1905259negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
BPIDAGO:2000157negative regulation of ubiquitin-specific protease activity
BPIEAGO:2000277positive regulation of oxidative phosphorylation uncoupler activity
BPIMPGO:2000679positive regulation of transcription regulatory region DNA binding
BPIMPGO:2000825positive regulation of androgen receptor activity
BPIMPGO:2001237negative regulation of extrinsic apoptotic signaling pathway
BPIMPGO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
MFICGO:0001047core promoter binding
MFIDAGO:0003690double-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIGIGO:0003713transcription coactivator activity
MFTASGO:0003713transcription coactivator activity
MFIDAGO:0003729mRNA binding
MFIPIGO:0005102signaling receptor binding
MFIDAGO:0005507copper ion binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0008233peptidase activity
MFIDAGO:0016532superoxide dismutase copper chaperone activity
MFIDAGO:0016684oxidoreductase activity, acting on peroxide as acceptor
MFIPIGO:0019899enzyme binding
MFIPIGO:0019900kinase binding
MFIPIGO:0019955cytokine binding
MFIDAGO:0036470tyrosine 3-monooxygenase activator activity
MFIDAGO:0036478L-dopa decarboxylase activator activity
MFIBAGO:0036524protein deglycase activity
MFIDAGO:0036524protein deglycase activity
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0044388small protein activating enzyme binding
MFIPIGO:0044390ubiquitin-like protein conjugating enzyme binding
MFHDAGO:0045296cadherin binding
MFIDAGO:0045340mercury ion binding
MFIPIGO:0050681androgen receptor binding
MFIEAGO:0051920peroxiredoxin activity
MFIPIGO:0070491repressing transcription factor binding
MFIPIGO:0097110scaffold protein binding
MFIDAGO:1903135cupric ion binding
MFIDAGO:1903136cuprous ion binding
MFIPIGO:1990381ubiquitin-specific protease binding

Gene expression in normal tissue: PARK7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PARK7


DatabasePathway IDPathway Des.
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP2267Synaptic Vesicle Pathway
wikipathwaysWP2371Parkinsons Disease Pathway
pidalphasynuclein_pathwayAlpha-synuclein signaling
kegghsa05012Parkinson,s disease - Homo sapiens (human)
netpathPathway_AndrogenReceptorAndrogenReceptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD33Entinostat1
iGMDRD798Ceranib-21
iGMDRD151CHM-11
iGMDRD256NVP-2311
iGMDRD646PHA-7938871
iGMDRD106Clofarabine1
iGMDRD552AZD-17751

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PARK7

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