RAD51
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAD51 recombinase | MIM:179617 | Ensembl:ENSG00000285396 | HGNC:HGNC:9817 | PA34176 | 15q15.1 |
GO terms in RAD51
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000150 | recombinase activity |
| MF | IBA | GO:0000400 | four-way junction DNA binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IMP | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0003697 | single-stranded DNA binding |
| MF | IDA | GO:0003697 | single-stranded DNA binding |
| MF | IMP | GO:0003697 | single-stranded DNA binding |
| MF | IBA | GO:0004520 | endodeoxyribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IBA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0043142 | single-stranded DNA-dependent ATPase activity |
| MF | IMP | GO:0043142 | single-stranded DNA-dependent ATPase activity |
| MF | IPI | GO:0070182 | DNA polymerase binding |
| BP | IBA | GO:0000707 | meiotic DNA recombinase assembly |
| BP | ISS | GO:0000722 | telomere maintenance via recombination |
| BP | IDA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IBA | GO:0000730 | DNA recombinase assembly |
| BP | IMP | GO:0000730 | DNA recombinase assembly |
| BP | IDA | GO:0006268 | DNA unwinding involved in DNA replication |
| BP | TAS | GO:0006281 | DNA repair |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | IBA | GO:0006312 | mitotic recombination |
| BP | TAS | GO:0006312 | mitotic recombination |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0007131 | reciprocal meiotic recombination |
| BP | TAS | GO:0007131 | reciprocal meiotic recombination |
| BP | IBA | GO:0010212 | response to ionizing radiation |
| BP | IDA | GO:0010569 | regulation of double-strand break repair via homologous recombination |
| BP | ISS | GO:0010833 | telomere maintenance via telomere lengthening |
| BP | IDA | GO:0031297 | replication fork processing |
| BP | IMP | GO:0031297 | replication fork processing |
| BP | IMP | GO:0036297 | interstrand cross-link repair |
| BP | IBA | GO:0042148 | strand invasion |
| BP | IDA | GO:0051106 | positive regulation of DNA ligation |
| BP | IPI | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0051321 | meiotic cell cycle |
| BP | IBA | GO:0070192 | chromosome organization involved in meiotic cell cycle |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| BP | IDA | GO:0071479 | cellular response to ionizing radiation |
| BP | IDA | GO:0072757 | cellular response to camptothecin |
| BP | IEA | GO:1990426 | mitotic recombination-dependent replication fork processing |
| CC | IDA | GO:0000228 | nuclear chromosome |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | ISS | GO:0000793 | condensed chromosome |
| CC | IBA | GO:0000794 | condensed nuclear chromosome |
| CC | ISS | GO:0000794 | condensed nuclear chromosome |
| CC | IDA | GO:0000800 | lateral element |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005657 | replication fork |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| CC | IDA | GO:0035861 | site of double-strand break |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: RAD51
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD51
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP186 | Homologous recombination |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP707 | DNA Damage Response |
| pid | atr_pathway | ATR signaling pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | p73pathway | p73 transcription factor network |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | atrbrcapathway | role of brca1 brca2 and atr in cancer susceptibility |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-912446 | Meiotic recombination |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD51
CLASSFICATION
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