Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].

RAD51 recombinaseMIM:179617Ensembl:ENSG00000285396HGNC:HGNC:9817PA3417615q15.1

GO terms in RAD51

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000150recombinase activity
MFIBAGO:0000400four-way junction DNA binding
MFIBAGO:0003690double-stranded DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIMPGO:0003690double-stranded DNA binding
MFIBAGO:0003697single-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIMPGO:0003697single-stranded DNA binding
MFIBAGO:0004520endodeoxyribonuclease activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIPIGO:0008022protein C-terminus binding
MFIBAGO:0008094DNA-dependent ATPase activity
MFIPIGO:0042802identical protein binding
MFIDAGO:0043142single-stranded DNA-dependent ATPase activity
MFIMPGO:0043142single-stranded DNA-dependent ATPase activity
MFIPIGO:0070182DNA polymerase binding
BPIBAGO:0000707meiotic DNA recombinase assembly
BPISSGO:0000722telomere maintenance via recombination
BPIDAGO:0000724double-strand break repair via homologous recombination
BPIMPGO:0000724double-strand break repair via homologous recombination
BPTASGO:0000724double-strand break repair via homologous recombination
BPIBAGO:0000730DNA recombinase assembly
BPIMPGO:0000730DNA recombinase assembly
BPIDAGO:0006268DNA unwinding involved in DNA replication
BPTASGO:0006281DNA repair
BPTASGO:0006310DNA recombination
BPIBAGO:0006312mitotic recombination
BPTASGO:0006312mitotic recombination
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0007131reciprocal meiotic recombination
BPTASGO:0007131reciprocal meiotic recombination
BPIBAGO:0010212response to ionizing radiation
BPIDAGO:0010569regulation of double-strand break repair via homologous recombination
BPISSGO:0010833telomere maintenance via telomere lengthening
BPIDAGO:0031297replication fork processing
BPIMPGO:0031297replication fork processing
BPIMPGO:0036297interstrand cross-link repair
BPIBAGO:0042148strand invasion
BPIDAGO:0051106positive regulation of DNA ligation
BPIPIGO:0051260protein homooligomerization
BPISSGO:0051321meiotic cell cycle
BPIBAGO:0070192chromosome organization involved in meiotic cell cycle
BPTASGO:0070317negative regulation of G0 to G1 transition
BPIDAGO:0071479cellular response to ionizing radiation
BPIDAGO:0072757cellular response to camptothecin
BPIEAGO:1990426mitotic recombination-dependent replication fork processing
CCIDAGO:0000228nuclear chromosome
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000790nuclear chromatin
CCISSGO:0000793condensed chromosome
CCIBAGO:0000794condensed nuclear chromosome
CCISSGO:0000794condensed nuclear chromosome
CCIDAGO:0000800lateral element
CCIBAGO:0005657replication fork
CCIEAGO:0005759mitochondrial matrix
CCIEAGO:0005815microtubule organizing center
CCIDAGO:0016605PML body
CCIDAGO:0032991protein-containing complex
CCIBAGO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex
CCIDAGO:0035861site of double-strand break
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: RAD51

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAD51

DatabasePathway IDPathway Des.
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP186Homologous recombination
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP707DNA Damage Response
pidatr_pathwayATR signaling pathway
pidbard1pathwayBARD1 signaling events
pidp73pathwayp73 transcription factor network
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
biocartaatmpathwayatm signaling pathway
biocartaatrbrcapathwayrole of brca1 brca2 and atr in cancer susceptibility
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953750Transcriptional Regulation by E2F6
reactomeR-HSA-912446Meiotic recombination

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAD51