TLR4


Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:603030
PHARMGKB IDPA36552
Map Location9q33.1

GO terms in TLR4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0001530 lipopolysaccharide binding
MF IMP GO:0001530 lipopolysaccharide binding
MF NAS GO:0001530 lipopolysaccharide binding
MF IBA GO:0001875 lipopolysaccharide receptor activity
MF IDA GO:0001875 lipopolysaccharide receptor activity
MF NAS GO:0004888 transmembrane signaling receptor activity
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Gene expression in normal tissue: TLR4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLR4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-1236974 ER-Phagosome pathway
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-140534 via Death Receptors in the presence of ligand
reactome R-HSA-1643685 Disease
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD263 AACOCF3 1
iGMDRD353 PD0325901 1
iGMDRD42 Vorinostat 3
iGMDRD322 FK 866 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLR4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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