XRN1
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 5'-3' exoribonuclease 1 | MIM:607994 | Ensembl:ENSG00000114127 | HGNC:HGNC:30654 | PA134878471 | 3q23 |
GO terms in XRN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0002151 | G-quadruplex RNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IMP | GO:0004534 | 5'-3' exoribonuclease activity |
| MF | ISS | GO:0004534 | 5'-3' exoribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0051880 | G-quadruplex DNA binding |
| MF | IC | GO:0070034 | telomerase RNA binding |
| CC | IEA | GO:0000932 | P-body |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0045202 | synapse |
| BP | IMP | GO:0000956 | nuclear-transcribed mRNA catabolic process |
| BP | IMP | GO:0016075 | rRNA catabolic process |
| BP | IEA | GO:0017148 | negative regulation of translation |
| BP | IC | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0071028 | nuclear mRNA surveillance |
| BP | IMP | GO:0071044 | histone mRNA catabolic process |
| BP | IEA | GO:0071409 | cellular response to cycloheximide |
| BP | ISS | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic |
| BP | IEA | GO:1905795 | cellular response to puromycin |
Gene expression in normal tissue: XRN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XRN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease |
| reactome | R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| reactome | R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD475 | BX 912 | 1 |
| iGMDRD589 | HG-5-113-01 | 1 |
| iGMDRD593 | CX-5461 | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD378 | ZM-447439 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XRN1
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