XRN1


Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
5'-3' exoribonuclease 1MIM:607994Ensembl:ENSG00000114127HGNC:HGNC:30654PA1348784713q23

GO terms in XRN1


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0002151G-quadruplex RNA binding
MFHDAGO:0003723RNA binding
MFIMPGO:00045345'-3' exoribonuclease activity
MFISSGO:00045345'-3' exoribonuclease activity
MFIPIGO:0005515protein binding
MFISSGO:0051880G-quadruplex DNA binding
MFICGO:0070034telomerase RNA binding
CCIEAGO:0000932P-body
CCIEAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIEAGO:0030425dendrite
CCIEAGO:0043025neuronal cell body
CCIEAGO:0045202synapse
BPIMPGO:0000956nuclear-transcribed mRNA catabolic process
BPIMPGO:0016075rRNA catabolic process
BPIEAGO:0017148negative regulation of translation
BPICGO:0032211negative regulation of telomere maintenance via telomerase
BPIEAGO:0033574response to testosterone
BPTASGO:0043488regulation of mRNA stability
BPIMPGO:0071028nuclear mRNA surveillance
BPIMPGO:0071044histone mRNA catabolic process
BPIEAGO:0071409cellular response to cycloheximide
BPISSGO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic
BPIEAGO:1905795cellular response to puromycin

Gene expression in normal tissue: XRN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XRN1


DatabasePathway IDPathway Des.
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)
kegghsa03018RNA degradation - Homo sapiens (human)
reactomeR-HSA-429914Deadenylation-dependent mRNA decay
reactomeR-HSA-430039mRNA decay by 5' to 3' exoribonuclease
reactomeR-HSA-450385Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
reactomeR-HSA-450513Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD564GSK-6503941
iGMDRD313Axitinib1
iGMDRD475BX 9121
iGMDRD589HG-5-113-011
iGMDRD593CX-54611
iGMDRD397Pazopanib1
iGMDRD241Sunitinib1
iGMDRD378ZM-4474392

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XRN1

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