DDIT3


Summary: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA damage inducible transcript 3MIM:126337Ensembl:ENSG00000175197HGNC:HGNC:2726PA2719312q13.3

GO terms in DDIT3


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005770late endosome
CCTASGO:0005829cytosol
CCIDAGO:0032993protein-DNA complex
CCISSGO:0035976transcription factor AP-1 complex
CCIBAGO:0036488CHOP-C/EBP complex
CCISSGO:0036488CHOP-C/EBP complex
CCTASGO:0036488CHOP-C/EBP complex
CCIBAGO:1990617CHOP-ATF4 complex
CCIDAGO:1990617CHOP-ATF4 complex
CCIPIGO:1990617CHOP-ATF4 complex
CCIBAGO:1990622CHOP-ATF3 complex
CCIDAGO:1990622CHOP-ATF3 complex
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIGIGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001955blood vessel maturation
BPIMPGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0006983ER overload response
BPIDAGO:0006986response to unfolded protein
BPIDAGO:0007050cell cycle arrest
BPIEAGO:0016055Wnt signaling pathway
BPIMPGO:0032757positive regulation of interleukin-8 production
BPIDAGO:0032792negative regulation of CREB transcription factor activity
BPIGIGO:0032792negative regulation of CREB transcription factor activity
BPIDAGO:0034976response to endoplasmic reticulum stress
BPTASGO:0036499PERK-mediated unfolded protein response
BPTASGO:0036500ATF6-mediated unfolded protein response
BPIEAGO:0042594response to starvation
BPIDAGO:0042789mRNA transcription by RNA polymerase II
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIMPGO:0043433negative regulation of DNA-binding transcription factor activity
BPICGO:0043525positive regulation of neuron apoptotic process
BPTASGO:0043620regulation of DNA-templated transcription in response to stress
BPISSGO:0044324regulation of transcription involved in anterior/posterior axis specification
BPIDAGO:0045454cell redox homeostasis
BPIEAGO:0045599negative regulation of fat cell differentiation
BPIEAGO:0045662negative regulation of myoblast differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051209release of sequestered calcium ion into cytosol
BPIDAGO:0051259protein complex oligomerization
BPIMPGO:0051898negative regulation of protein kinase B signaling
BPIBAGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIDAGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIMPGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPTASGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIEAGO:0072655establishment of protein localization to mitochondrion
BPISSGO:0090090negative regulation of canonical Wnt signaling pathway
BPICGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPIDAGO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
BPIDAGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
BPIGIGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
BPIMPGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
BPISSGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
BPIEAGO:1990442intrinsic apoptotic signaling pathway in response to nitrosative stress
BPIDAGO:2000016negative regulation of determination of dorsal identity
MFIDAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFICGO:0003700DNA-binding transcription factor activity
MFIGIGO:0003700DNA-binding transcription factor activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIPIGO:0008140cAMP response element binding protein binding
MFIDAGO:0042803protein homodimerization activity
MFISSGO:0042803protein homodimerization activity
MFIDAGO:0043522leucine zipper domain binding
MFICGO:0044212transcription regulatory region DNA binding
MFISSGO:0044212transcription regulatory region DNA binding
MFIPIGO:0046982protein heterodimerization activity
MFNASGO:0046982protein heterodimerization activity
MFTASGO:0046982protein heterodimerization activity

Gene expression in normal tissue: DDIT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDIT3


DatabasePathway IDPathway Des.
pidatf2_pathwayATF-2 transcription factor network
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
netpathPathway_RAGERAGE
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
wikipathwaysWP236Adipogenesis
wikipathwaysWP2655ATF6 (ATF6-alpha) activates chaperone genes
wikipathwaysWP2753ATF4 activates genes
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP4211Transcriptional cascade regulating adipogenesis
reactomeR-HSA-380994ATF4 activates genes
reactomeR-HSA-381033ATF6 (ATF6-alpha) activates chaperones
reactomeR-HSA-381042PERK regulates gene expression
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-381183ATF6 (ATF6-alpha) activates chaperone genes
reactomeR-HSA-392499Metabolism of proteins
biocartap38mapkpathwayp38 mapk signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD77Itraconazole1
iGMDRD150RITA3
iGMDRD886Compound 1541A3
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDIT3

​​​​