Summary: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].

coagulation factor XIIMIM:610619Ensembl:ENSG00000131187HGNC:HGNC:3530PA1615q35.3

Gene Categories:


GO terms in F12

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0002353plasma kallikrein-kinin cascade
BPIDAGO:0002542Factor XII activation
BPICGO:0007597blood coagulation, intrinsic pathway
BPTASGO:0007597blood coagulation, intrinsic pathway
BPIDAGO:0010756positive regulation of plasminogen activation
BPIDAGO:0016485protein processing
BPIDAGO:0016540protein autoprocessing
BPIDAGO:0030194positive regulation of blood coagulation
BPIDAGO:0031638zymogen activation
BPTASGO:0045087innate immune response
BPIDAGO:0051788response to misfolded protein
BPIDAGO:0051919positive regulation of fibrinolysis
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIBAGO:0005791rough endoplasmic reticulum
CCTASGO:0005886plasma membrane
CCHDAGO:0070062extracellular exosome
MFIBAGO:0004252serine-type endopeptidase activity
MFIDAGO:0004252serine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFICGO:0051787misfolded protein binding

Gene expression in normal tissue: F12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in F12

DatabasePathway IDPathway Des.
biocartaintrinsicpathwayintrinsic prothrombin activation pathway
reactomeR-HSA-140837Intrinsic Pathway of Fibrin Clot Formation
reactomeR-HSA-140877Formation of Fibrin Clot (Clotting Cascade)
wikipathwaysWP272Blood Clotting Cascade
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3897Dengue-2 Interactions with Blood Clotting Cascade
wikipathwaysWP558Complement and Coagulation Cascades
smpdbSMP00268Warfarin Action Pathway
smpdbSMP00269Acenocoumarol Action Pathway
smpdbSMP00270Dicumarol Action Pathway
smpdbSMP00271Phenprocoumon Action Pathway
smpdbSMP00272Enoxaparin Action Pathway
smpdbSMP00273Fondaparinux Action Pathway
smpdbSMP00274Heparin Action Pathway
smpdbSMP00275Ardeparin Action Pathway
smpdbSMP00276Argatroban Action Pathway
smpdbSMP00277Bivalirudin Action Pathway
smpdbSMP00278Lepirudin Action Pathway
smpdbSMP00279Ximelagatran Action Pathway
smpdbSMP00280Alteplase Action Pathway
smpdbSMP00281Anistreplase Action Pathway
smpdbSMP00282Streptokinase Action Pathway
smpdbSMP00283Tenecteplase Action Pathway
smpdbSMP00284Urokinase Action Pathway
smpdbSMP00285Reteplase Action Pathway
smpdbSMP00286Aminocaproic Acid Action Pathway
smpdbSMP00287Tranexamic Acid Action Pathway
smpdbSMP00288Aprotinin Action Pathway
smpdbSMP00655Phenindione Action Pathway
smpdbSMP00656Dicoumarol Action Pathway
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in F12