MAX


Summary: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MYC associated factor XMIM:154950Ensembl:ENSG00000125952HGNC:HGNC:6913PA3065614q23.3

GO terms in MAX


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0016605PML body
CCIEAGO:0030425dendrite
CCIMPGO:0032993protein-DNA complex
CCIDAGO:0071339MLL1 complex
CCIBAGO:0090575RNA polymerase II transcription factor complex
CCIDAGO:0090575RNA polymerase II transcription factor complex
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0009267cellular response to starvation
BPIEAGO:0032868response to insulin
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048678response to axon injury
BPIEAGO:0051402neuron apoptotic process
BPIEAGO:0060041retina development in camera-type eye
BPIEAGO:0065003protein-containing complex assembly
BPTASGO:0070317negative regulation of G0 to G1 transition
BPIEAGO:0071375cellular response to peptide hormone stimulus
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIMPGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0003712transcription coregulator activity
MFTASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIMPGO:0042803protein homodimerization activity
MFIEAGO:0044877protein-containing complex binding
MFIEAGO:0046982protein heterodimerization activity
MFIMPGO:0070888E-box binding

Gene expression in normal tissue: MAX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAX


DatabasePathway IDPathway Des.
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidmyc_pathwayC-MYC pathway
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
pidtelomerasepathwayRegulation of Telomerase
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
biocartamapkpathwaymapkinase signaling pathway
biocartap38mapkpathwayp38 mapk signaling pathway
biocartatertpathwayoverview of telomerase protein component gene htert transcriptional regulation
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953750Transcriptional Regulation by E2F6

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD870BRD636104
iGMDRD782DC-45-A22
iGMDRD434BMS-5369242
iGMDRD84Lovastatin acid3
iGMDRD82Quiflapon3
iGMDRD886Compound 1541A2
iGMDRD61Kinetin riboside3
iGMDRD316N9-Isopropyl-olomoucine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAX

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