MRE11


Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MRE11


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000781 chromosome, telomeric region
CC HDA GO:0000784 nuclear chromosome, telomeric region
CC IBA GO:0000784 nuclear chromosome, telomeric region
CC IDA GO:0000784 nuclear chromosome, telomeric region
CC IDA GO:0000784 nuclear chromosome, telomeric region
CC ISS GO:0000784 nuclear chromosome, telomeric region
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Gene expression in normal tissue: MRE11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRE11


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Database
Pathway ID
Pathway Des.
pid atm_pathway ATM pathway
pid bard1pathway BARD1 signaling events
pid deltanp63pathway Validated transcriptional targets of deltaNp63 isoforms
pid fanconi_pathway Fanconi anemia pathway
pid telomerasepathway Regulation of Telomerase
kegg hsa03440 Homologous recombination - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD150 RITA 4
iGMDRD532 Olaparib 1
iGMDRD116 CD437 3
iGMDRD427 ABT737 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRE11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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