MRE11
Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:600814 Ensembl IDEnsembl:ENSG00000020922 HGNC IDHGNC:HGNC:7230 PHARMGKB IDPA30934 Map Location11q21 |
GO terms in MRE11
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0000781 | chromosome, telomeric region |
CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IBA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | ISS | GO:0000784 | nuclear chromosome, telomeric region |
Gene expression in normal tissue: MRE11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRE11
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | atm_pathway | ATM pathway |
pid | bard1pathway | BARD1 signaling events |
pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
pid | fanconi_pathway | Fanconi anemia pathway |
pid | telomerasepathway | Regulation of Telomerase |
kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRE11
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |