MSH5


Summary: This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mutS homolog 5MIM:603382Ensembl:ENSG00000204410HGNC:HGNC:7328PA311366p21.33

Gene Categories:

DNA REPAIR

GO terms in MSH5


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000712resolution of meiotic recombination intermediates
BPIBAGO:0006298mismatch repair
BPIBAGO:0007131reciprocal meiotic recombination
BPIBAGO:0007292female gamete generation
BPIBAGO:0045143homologous chromosome segregation
BPIBAGO:0051026chiasma assembly
CCIBAGO:0000228nuclear chromosome
CCIBAGO:0000795synaptonemal complex
CCIBAGO:0032300mismatch repair complex
MFIBAGO:0003684damaged DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008094DNA-dependent ATPase activity
MFIBAGO:0030983mismatched DNA binding

Gene expression in normal tissue: MSH5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSH5


DatabasePathway IDPathway Des.
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-912446Meiotic recombination
wikipathwaysWP34Ovarian Infertility Genes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide3
iGMDRD399Selumetinib3
iGMDRD499PDMP3
iGMDRD280CYTOCHALASIN B1
iGMDRD883CIL55A1
iGMDRD483SCH-5290743

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSH5

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