Summary: This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].

NIMA related kinase 2MIM:604043Ensembl:ENSG00000117650HGNC:HGNC:7745PA315461q32.3

GO terms in NEK2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019903protein phosphatase binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0000070mitotic sister chromatid segregation
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0000278mitotic cell cycle
BPIEAGO:0001824blastocyst development
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPIDAGO:0007059chromosome segregation
BPTASGO:0007088regulation of mitotic nuclear division
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPIEAGO:0043392negative regulation of DNA binding
BPIMPGO:0046602regulation of mitotic centrosome separation
BPTASGO:0046602regulation of mitotic centrosome separation
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0046777protein autophosphorylation
BPTASGO:0051225spindle assembly
BPIDAGO:0051299centrosome separation
BPIEAGO:0051301cell division
BPIEAGO:0051321meiotic cell cycle
BPIMPGO:0051973positive regulation of telomerase activity
BPIMPGO:0051988regulation of attachment of spindle microtubules to kinetochore
BPIEAGO:0090307mitotic spindle assembly
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPIMPGO:1903126negative regulation of centriole-centriole cohesion
BPIMPGO:1904355positive regulation of telomere capping
CCIEAGO:0000777condensed chromosome kinetochore
CCIEAGO:0000794condensed nuclear chromosome
CCIEAGO:0000922spindle pole
CCIMPGO:0032991protein-containing complex

Gene expression in normal tissue: NEK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEK2

DatabasePathway IDPathway Des.
pidfoxm1pathwayFOXM1 transcription factor network
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-179409APC-Cdc20 mediated degradation of Nek2A
reactomeR-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8854518AURKA Activation by TPX2

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside6
iGMDRD584VER 1550081
iGMDRD886Compound 1541A3
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK2