PDGFA


Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
platelet derived growth factor subunit AMIM:173430Ensembl:ENSG00000197461HGNC:HGNC:8799PA331447p22.3

GO terms in PDGFA


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005161platelet-derived growth factor receptor binding
MFIDAGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0005518collagen binding
MFIDAGO:0008083growth factor activity
MFIDAGO:0042803protein homodimerization activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIPIGO:0046982protein heterodimerization activity
MFIPIGO:0048407platelet-derived growth factor binding
MFIBAGO:0070851growth factor receptor binding
CCTASGO:0000139Golgi membrane
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005796Golgi lumen
CCISSGO:0005902microvillus
CCIDAGO:0009986cell surface
CCTASGO:0031093platelet alpha granule lumen
BPTASGO:0000165MAPK cascade
BPISSGO:0001525angiogenesis
BPTASGO:0001775cell activation
BPISSGO:0001942hair follicle development
BPISSGO:0002053positive regulation of mesenchymal cell proliferation
BPTASGO:0002576platelet degranulation
BPTASGO:0007267cell-cell signaling
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0009611response to wounding
BPISSGO:0009887animal organ morphogenesis
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010512negative regulation of phosphatidylinositol biosynthetic process
BPIDAGO:0010544negative regulation of platelet activation
BPIBAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIDAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIDAGO:0014910regulation of smooth muscle cell migration
BPISSGO:0030031cell projection assembly
BPISSGO:0030036actin cytoskeleton organization
BPTASGO:0030198extracellular matrix organization
BPIBAGO:0030335positive regulation of cell migration
BPIDAGO:0030335positive regulation of cell migration
BPIBAGO:0031954positive regulation of protein autophosphorylation
BPIDAGO:0031954positive regulation of protein autophosphorylation
BPTASGO:0032956regulation of actin cytoskeleton organization
BPIDAGO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
BPTASGO:0042060wound healing
BPIBAGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIMPGO:0043410positive regulation of MAPK cascade
BPISSGO:0043588skin development
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIBAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIDAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIDAGO:0048146positive regulation of fibroblast proliferation
BPISSGO:0048286lung alveolus development
BPISSGO:0050730regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050919negative chemotaxis
BPIEAGO:0051781positive regulation of cell division
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPTASGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0060683regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0072124regulation of glomerular mesangial cell proliferation
BPISSGO:1990401embryonic lung development
BPIDAGO:2000278regulation of DNA biosynthetic process

Gene expression in normal tissue: PDGFA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDGFA


DatabasePathway IDPathway Des.
biocartacdc42racpathwayrole of pi3k subunit p85 in regulation of actin organization and cell migration
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartapdgfpathwaypdgf signaling pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2526PDGF Pathway
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP530Cytokines and Inflammatory Response
pidceramide_pathwayCeramide signaling pathway
pidpdgf_pathwayPDGF receptor signaling network
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide3
iGMDRD318PAC-13
iGMDRD121GMX17783
iGMDRD60Quinoclamine6
iGMDRD466Chaetocin3
iGMDRD679Bistramide A1
iGMDRD300Tozasertib6
iGMDRD23Gossypol3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDGFA

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