GO terms in PPP3R1


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0004723calcium-dependent protein serine/threonine phosphatase activity
MFNASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFNASGO:0005516calmodulin binding
MFIDAGO:0016018cyclosporin A binding
MFIPIGO:0019902phosphatase binding
MFIPIGO:0019904protein domain specific binding
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005955calcineurin complex
CCNASGO:0005955calcineurin complex
CCIEAGO:0042383sarcolemma
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIEAGO:0001837epithelial to mesenchymal transition
BPIEAGO:0006470protein dephosphorylation
BPIEAGO:0006606protein import into nucleus
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0007507heart development
BPIEAGO:0022011myelination in peripheral nervous system
BPIDAGO:0033173calcineurin-NFAT signaling cascade
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0060487lung epithelial cell differentiation

Gene expression in normal tissue: PPP3R1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP3R1


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-2025928Calcineurin activates NFAT
reactomeR-HSA-2025928Calcineurin activates NFAT
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5607763CLEC7A (Dectin-1) induces NFAT activation
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP428Wnt Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD562Navitoclax3
iGMDRD126Tipifarnib3
iGMDRD297Austocystin D3
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP3R1

​​​​