SOST


Summary: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sclerostinMIM:605740Ensembl:ENSG00000167941HGNC:HGNC:13771PA3780917q21.31

GO terms in SOST


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001503ossification
BPIEPGO:0009612response to mechanical stimulus
BPIEAGO:0016055Wnt signaling pathway
BPNASGO:0030279negative regulation of ossification
BPIDAGO:0030514negative regulation of BMP signaling pathway
BPIDAGO:0031333negative regulation of protein complex assembly
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0071374cellular response to parathyroid hormone stimulus
BPIDAGO:0090090negative regulation of canonical Wnt signaling pathway
BPTASGO:0090090negative regulation of canonical Wnt signaling pathway
BPIDAGO:2000054negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
CCTASGO:0005576extracellular region
CCIEAGO:0005615extracellular space
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0032991protein-containing complex
CCHDAGO:0062023collagen-containing extracellular matrix
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIEAGO:0008201heparin binding

Gene expression in normal tissue: SOST

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOST


DatabasePathway IDPathway Des.
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP428Wnt Signaling Pathway
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD562Navitoclax6
iGMDRD193Fqi13
iGMDRD466Chaetocin3
iGMDRD297Austocystin D3
iGMDRD154NSC237666

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOST

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