SPAG8


Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sperm associated antigen 8MIM:605731Ensembl:ENSG00000137098HGNC:HGNC:14105PA378439p13.3

GO terms in SPAG8


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007049cell cycle
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007338single fertilization
BPNDGO:0008150biological_process
BPIEAGO:0030154cell differentiation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
CCIEAGO:0001669acrosomal vesicle
CCIBAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005819spindle
CCNASGO:0016020membrane
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SPAG8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPAG8


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD375GW-4058332
iGMDRD267Oligomycin A5
iGMDRD420Leucascandrolide A3
iGMDRD367Ro 28-16751

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPAG8

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