SPAG8
Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sperm associated antigen 8 | MIM:605731 | Ensembl:ENSG00000137098 | HGNC:HGNC:14105 | PA37843 | 9p13.3 |
GO terms in SPAG8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007338 | single fertilization |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | NAS | GO:0016020 | membrane |
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SPAG8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPAG8
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD367 | Ro 28-1675 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPAG8
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