TIGAR


Summary: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TP53 induced glycolysis regulatory phosphataseMIM:610775Ensembl:ENSG00000078237HGNC:HGNC:1185PA2550612p13.32

Gene Categories:

DNA REPAIRKINASE

GO terms in TIGAR


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005622intracellular
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005741mitochondrial outer membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPISSGO:0002931response to ischemia
BPIDAGO:0006003fructose 2,6-bisphosphate metabolic process
BPIEAGO:0006914autophagy
BPIEAGO:0006915apoptotic process
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0009410response to xenobiotic stimulus
BPIEAGO:0010332response to gamma radiation
BPIEAGO:0010666positive regulation of cardiac muscle cell apoptotic process
BPIEAGO:0016311dephosphorylation
BPIDAGO:0030388fructose 1,6-bisphosphate metabolic process
BPIDAGO:0043069negative regulation of programmed cell death
BPIMPGO:0043456regulation of pentose-phosphate shunt
BPIMPGO:0045739positive regulation of DNA repair
BPIEAGO:0045820negative regulation of glycolytic process
BPIEAGO:0060576intestinal epithelial cell development
BPIDAGO:0071279cellular response to cobalt ion
BPIDAGO:0071456cellular response to hypoxia
BPIEAGO:1901215negative regulation of neuron death
BPIEAGO:1901525negative regulation of mitophagy
BPIMPGO:1902153regulation of response to DNA damage checkpoint signaling
BPIDAGO:1903301positive regulation of hexokinase activity
BPIEAGO:1904024negative regulation of glucose catabolic process to lactate via pyruvate
BPIEAGO:2000378negative regulation of reactive oxygen species metabolic process
MFIDAGO:0004083bisphosphoglycerate 2-phosphatase activity
MFEXPGO:0004331fructose-2,6-bisphosphate 2-phosphatase activity
MFIDAGO:0004331fructose-2,6-bisphosphate 2-phosphatase activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: TIGAR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIGAR


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa00051Fructose and mannose metabolism - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
pidp53downstreampathwayDirect p53 effectors
humancycPWY66-423fructose 2,6-bisphosphate synthesis
wikipathwaysWP3349TP53 Regulates Metabolic Genes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD692SB5908851
iGMDRD654SL 0101-11
iGMDRD163all trans Retinoic Acid1
iGMDRD109Gefitinib1
iGMDRD119Temsirolimus1
iGMDRD1036X17AAG1
iGMDRD431NU-74411

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIGAR

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