TNFRSF17
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 17 | MIM:109545 | Ensembl:ENSG00000048462 | HGNC:HGNC:11913 | PA36606 | 16p13.13 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TNFRSF17
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0002260 | lymphocyte homeostasis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| MF | IEA | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: TNFRSF17
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF17
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | tall1pathway | yaci and bcma stimulation of b cell immune responses |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD135 | Lenalidomide | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD329 | Merck60 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF17
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